06Feb 2018

AUTOIMMUNE HEPATITIS AS A RARE CAUSE OF HEPATITIS IN A HUMAN IMMUNE DEFICIENCY VIRUS INFECTED PATIENT ON ANTIRETROVIRAL TREATMENT: A CASE REPORT.

  • Department Of Medicine, King George?s Medical University, Lucknow, India.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

The emergence of hepatic injury in patients with human immunodeficiency virus infection during highly active therapy presents a diagnostic dilemma. It may represent treatment side effects or Autoimmune disorders, such as autoimmune hepatitis, emerging during immune restoration. We present the case of a 25-year-old Indian woman with human immunodeficiency virus infection who presented to our emergency department with icterus, abdominal pain and was found to have autoimmune hepatitis. In our patient (the one patient case we are reporting), a liver biopsy revealed interface hepatitis, necrosis with lymphocytes and plasma cell infiltrates and variable degrees of fibrosis.

  1. Elhed A, Unutmaz D. Th17 cells and HIV infection. Curr Opin HIV AIDS. 2010;5:146?150. doi: 10.1097/COH.0b013e32833647a8.
  2. German V, Vassiloyanakopoulos A, Sampaziotis D, Giannakos G. Autoimmune hepatitis in an
  3. HIV infected patient that responded to antiretroviral therapy. Scand J Infect Dis. 2005;37:148?
  4. doi: 10.1080/00365540510026841.
  5. Puius YA, Dove LM, Brust DG, Shah DP, Lefkowitch JH. Three cases of autoimmune hepatitis in HIV-infected patients. J Clin Gastroenterol. 2008;42:425?429. doi:
  6. 1097/01.mcg.0000225591.08825.3e.
  7. O'Leary JG, Zachary K, Misdraji J, Chung RT. De novo autoimmune hepatitis during immune reconstitution in an HIV-infected patient receiving highly active antiretroviral therapy. Clin Infect Dis. 2008;46:e12?e14.
  8. Wan DW, Marks K, Yantiss RK, Talal AH. Autoimmune hepatitis in the HIV-infected patient: a therapeutic dilemma. AIDS Patient Care STDS. 2009;23:407?413. doi: 10.1089/apc.2008.0149.
  9. Vispo E, Maida I, Moreno A, Barreiro P, Soriano V. Autoimmune hepatitis induced by pegylated interferon in an HIV-infected patient with chronic hepatitis C. J Antimicrob Chemother. 2008;62:1470?1472. doi: 10.1093/jac/dkn416.
  10. Coriat R, Podevin P. Fulminant autoimmune hepatitis after successful interferon treatment in an HIV-HCV co-infected patient. Int J STD AIDS. 2008;19:208?210. doi: 10.1258/ijsa.2007.007185.
  11. Cazanave C, Rakotondravelo S, Morlat P, Blanco P, Bonnet F, Beylot J. Autoimmune hepatitis in a HIV-HCV co-infected patient: diagnostic and therapeutic difficulties in French. Rev Med Interne. 2006;27:414?419. doi: 10.1016/j.revmed.2006.01.016
  12. Diamantis I, Boumpas DT. Autoimmune hepatitis: evolving concepts. Autoimmun Rev 2004;3:207?14.
  13. O?Leary JG, Zachary K, Misdraji J, et al. De novo autoimmune hepatitis during immune reconstitution in an HIV-infected patient receiving highly active antiretroviral therapy. Clin Infect Dis 2008;46:e12?14
  14. German V, Vassiloyanakopoulos A, Sampaziotis D, et al. Autoimmune hepatitis in an HIV infected patient that responded to antiretroviral therapy. Scand J Infect Dis 2005;37:148?51.

[Vivek Kumar, Ajay Pratap Singh and Seetaram Singh Kulraj. (2018); AUTOIMMUNE HEPATITIS AS A RARE CAUSE OF HEPATITIS IN A HUMAN IMMUNE DEFICIENCY VIRUS INFECTED PATIENT ON ANTIRETROVIRAL TREATMENT: A CASE REPORT. Int. J. of Adv. Res. 6 (Feb). 529-531] (ISSN 2320-5407). www.journalijar.com

Ajay Pratap Singh
Department Of Medicine, King George\'s Medical University, Lucknow, Uttarpradesh, India

DOI:

Article DOI: 10.21474/IJAR01/6466      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6466

Download Full Paper

Download PDF No. of Downloads: 4 | No. of Views: 78