Effect of cinnamon on cypermethrin-induced nephrotoxicity in albino rats

The present work studied the effect of cinnamon on kidney injury induced by the pyrethroid insecticides,cypermethrin in albino rats. Animals were divided into 4 groups. Group 1: control, Group 2: given cinnamon (200mg/kg b.w), Group 3: given cypermethrin at a dose level 1/10 LD 50 of for 6 weeks, Group 4: given cypermethrin and cinnamon. Kidney cortex of cypermethrin-treated rats showed many histopathological alterations. The renal tubules lost their characteristic , the glomeruli were degenerated and the renal blood vessels were congested. The intertubular spaces were infiltrated by inflammatory leucocytic cells. Biochemical results showed that cypermethrin caused elevation in serum creatinine and urea. Moreover ,malondialdehyde (MDA) elevated and the antioxidant enzymes (SOD, CAT) decreased in kidney of cypermethrin-treated animals. Treating animals with cypermethrin and cinnamon led to an improvement in the histological structure of the kidney together with significant decrease in levels of creatinine and urea. Renal MDA was decreased and SOD and CAT were increased. The present results indicated that cinnamon has ameliorative effect against kidney damage induced by cypermethrin and this may be mediated by its antioxidant activity.