08Mar 2018

ASSESSMENT OF AQUEOUS AND ETHANOLIC EXTRACTS ANTIFUNGAL ACTIVITY FROM STEM BARKS OF ENANTIA POLYCARPA (ANNONACEAE) ON CANDIDA ALBICANS, ASPERGILLUS FLAVUS, ASPERGILLUS NIGER AND CRYPTOCOCCUS NEOFORMANS.

  • Biochemical Pharmacodynamics laboratory, University Felix Houphou?t Boigny (Ivory Coast).
  • Biochemistry-Microbiology laboratory, BIONAS Team, University Jean Lorougnon Gu?d? (Ivory Coast).
  • Biochemistry Medical and Fundamental, Pasteur institute of Cocody (Ivory Coast).
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The increase of mycosis and the development of resistance to usual antifungal stimulated the search for new antifungal coming from medicinal plants. This work?s aim was to evaluate the antifungal activity of aqueous and ethanolic extracts of Enantia polycarpa stem?s barks on the in vitro growth of Candida albicans, Cryptococcus neoformans, Aspergillus niger and Aspergillus flavus. Aqueous and 70% ethanolic extracts were tested on the fungi. The evaluation has been done by incorporating extracts in agar Sabouraud according the double dilution slant method. After 48 hours of incubation at 30⁰C. The germs have been sensitive to the two extracts according to a relation dose response relationship. 70% ethanolic extract (FMC=3,125 mg/mL on Candida albicans, FMC = 6,25 mg/mL on Cryptococcus neoformans and Aspergillus flavus and FMC = 12,50 mg/mL on Aspergillus niger) had the best activity. Candida albicans (FMC=3,125 mg/mL and IC50 = 1,80 mg/mL) was most sensitive. Thus, solvent hydro-alcoholic (70% ethanolic) concentrates better active ingredients of Enantia polycarpa.

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[OUATTARA Sitapha, KPOROU Kouassi Elisee, YAO Kouakou, KRA Adou Koffi Mathieu, GUESSAN Jean David and DJAMAN Allico Joseph. (2018); ASSESSMENT OF AQUEOUS AND ETHANOLIC EXTRACTS ANTIFUNGAL ACTIVITY FROM STEM BARKS OF ENANTIA POLYCARPA (ANNONACEAE) ON CANDIDA ALBICANS, ASPERGILLUS FLAVUS, ASPERGILLUS NIGER AND CRYPTOCOCCUS NEOFORMANS. Int. J. of Adv. Res. 6 (Mar). 648-657] (ISSN 2320-5407). www.journalijar.com

OUATTARA Sitapha
Félix Houphouët Boigny's university

DOI:

Article DOI: 10.21474/IJAR01/6714      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6714

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