Vol. 6 (11) pp. 495-497 DOI: 10.21474/IJAR01/8022

ISOLATION, CHARACTERIZATION AND RADICAL SCAVENGING SCREENING OF LIGNANS AND ALKALOIDS FROM CALONCOBA GLAUCA (FLACOURTIACEAE).

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  • Faculty of Sciences, University of Sciences and Techniques of Masuku, p.o. Box 943, Franceville, Gabon.
  • Faculty of Sciences, University of Dschang, p.o. Box 67, Dschang, Cameroon.
  • Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
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Abstract

Caloncoba glauca, a plant from Central Africa (Cameroun, Gabon), it’s used for healing skin diseases. The aim of this work is to carry out the phytochemical study of this plant as well as to evaluate the free-radical scavenging activity of its constituents. Repeated silica gel column chromatography followed by Sephadex LH-20 were used to isolate four compounds and their structures were elucidated using spectroscopic analysis, and comparison with published data. The free-radical scavenging assay on a microplate using DPPH was carried out to evaluate the antioxidant activity of the samples. These spectroscopic data allowed us to identify a lignan (sesamin), an alkaloid (dictamine) and a triterpene (lupeol). Lignans and alkaloids have been isolated for the first time from this plant species. The antiradical activity has been highlighted by the use of bio autographic method and disclosed to DDPH. As results, the ethyl acetate extract, sesamin and dictamine revealed antiradical activity. This work reveals the antioxidant activity of sesamin and dictamine. We are currently identifying other compounds and investigating cytotoxicity and other pharmacological activities with the anticancerous potential.

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How to Cite This Article

Raphael Bikanga, Jabar B. Pacme Abdul Achimi Agbo, James Deke Simo Mpetga, Rolande Bertille Nguemo Tsafack, Maurice Ducret Awouafack, Morita Hiroyuki, Pierre Tane and Jacques Lebib (2018); ISOLATION, CHARACTERIZATION AND RADICAL SCAVENGING SCREENING OF LIGNANS AND ALKALOIDS FROM CALONCOBA GLAUCA (FLACOURTIACEAE)., International Journal of Advanced Research (IJAR), 6 (11), 495-497, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/8022

Corresponding Author

RAPHAËL BIKANGA
FACULTY OF SCIENCE, UNIVERSITY OF SCIENCES AND TECHNICS OF MASUKU, P.O. BOX 943, FRANCEVILLE, GABON

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References

  1. Agbo, A.A J.B.P., Mpetga, S.D J., Bikanga, R., Tchuenguem, R.T., Tsafack, N.R.B., Awouafack, M.D., Dzoyem, J.P., Ito, T., Morita, H., Tan?, P. (2017). ?A New Benzophenanthridine Alkaloid from Caloncoba glauca.? Natural Product Communications., 12 (3): 367-368.
  2. Brand-Williams, W., Cuvelier , M.E., Berset, C. (1995). ?Use of a free radical method to evaluate antioxidant activity.? Food Science and Technology., 28 (1): 25-30.
  3. Burkill, H M. (1994). The useful plants of west tropical Africa. 2. Kew Royal Botanic Gardens. England.
  4. Giner, R M., Gray A.I., Gibbons S., Waterman P.G. (1993). ?Friedelane triterpenes from the stem bark of Caloncoba glauca.? Phytochemistry., 33 (1): 237-239.
  5. Mpetga, J.D.S., Tene, M., Wabo, K.H., Li, S.F., Kong, L.M., He, H.P., Hao, X.J, Tan?, P. (2012). ?Cytotoxic cycloartanes from the fruits of Caloncoba glauca.? Phytochemistry Letters., 5 (1): 183-187.
  6. Ziegler, H.L., Staerk, D,. Christiensen J., Olsen C.E., Sittie, A.A,. Jarosweski, J.W. (2002). ?New dammarane and malabaricane triterpenes from Caloncoba echinata.? Journal of Natural Products., 65: 1764-1765.
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