Vol. 6 (09) pp. 1045-1049 DOI: 10.21474/IJAR01/7769

EVALUATION THE EFFECT OF THE MALARIA PARASITE ON PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME LEVELS AMONG SUDANESE PATIENT IN KHARTOUM STATE- SUDAN.

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  • Department of Hematology and Immunohematology, College of Medical Laboratory Science, Sudan University ofScience and Technology, Khartoum, Sudan.
  • Head Department of Parasitology and Medical Entomology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
  • Department of Parasitology and Medical Entomology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
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Abstract

The hemostatic alterations play an important role in malaria pathogenesis and in the progression of disease. In severe infection the accelerated coagulation cascade activity with accelerated fibrinogen turnover increase the bleeding tendency and may lead to DIC. The present study was aimed to determine the effect of malaria parasites on Prothrombin Time and Activated Partial Thromboplastin Time Levels. A single citrated blood sample of patients diagnosed with malaria was analysed in semi- automated coagulation analyzer at the time of presentation, the values were compared with healthy controls. Data was analyzed by mean standard deviation and by ?t? test using SPSS software version 16. PT and APTT were significantly raised in cases when compared to control group, prolonged APTT is observed in 44% (P.value.001) and prolonged PT is observed in 43% of cases (P. value .016), the mean of PT (15.73 sec), and the mean of APTT (40.24 sec) in cases group. The mean of PT and APTT in control group, (13.94 sec), (30.87 sec) respectively. This study concluded that malaria infection altered the blood coagulation mechanism causing significant prolongation in PT and APTT.

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How to Cite This Article

Sarah Mahmoud Abdabagi, Fayhaa Mohammed Altayeb, Ahmed BakheetAbdAlla,RaniaAbdAlrhaman Osman and Ali ElaminNasir. (2018); EVALUATION THE EFFECT OF THE MALARIA PARASITE ON PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME LEVELS AMONG SUDANESE PATIENT IN KHARTOUM STATE- SUDAN., Int. J. of Adv. Res., 6 (09), 1045-1049, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/7769

Corresponding Author

Ahmed Bakheet Abd Alla
Assistant proffessor
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.