17Sep 2018

MATERNAL CHRONIC DISEASES AS RISK FACTOR OF CYANOTIC HEART DEFECTS (FALLOT TETRALOGY & PDA) AMONG CHILDREN IN MALLAWY CITY.

  • Department of Public health and preventive medicine, Faculty of Medicine, Minia University, Egypt.
  • Department of Pediatrics, Faculty of Medicine, Minia University, Egypt.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Information about known risk factors for cyanotic congenital heart defects is deficient. This study aimed to investigate the relationship between maternal chronic disease and cyanotic congenital heart disease in offspring. Cyanotic congenital heart defects (CHDs) are associated with multiple risk factors such as maternal febrile illness, maternal Hypertension (HTN), Diabetes Mellitus (DM), SLE, Epilepsy, and birth weight of the child. The current study was aimed to study the relationship between some maternal chronic diseases and the development of common cyanotic congenital heart defects. A cross-sectional study was done on patients attending the pediatric outpatient clinic in Mallawy general hospital from October 2016 to April 2017. A total of 100 patients were included in the study. It was found that the most 2 common types of cyanotic congenital heart diseases were PDA and Fallot tetralogy there was a positive significant association (p<0.05) between ( maternal DM, maternal HTN, maternal infection and maternal history of receiving medications) and occurrence of cyanotic CHD

  1. Abou-Taleb, A., Abdelhamid, M. A., & Bahkeet, M. A. (2016). Clinical profile of cyanotic congenital heart disease in the neonatal intensive care unit at Sohag University Hospital, Upper Egypt. Egyptian Journal of Medical Human Genetics.
  2. Alverson CJ, Strickland MJ, Gilboa SM, and Correa A. Maternal smoking and congenital heart defects in the Baltimore- Washington Infant Study. Pediatrics 2011; 127:647?653.
  3. Atwa ZT and Safar The outcome of congenital heart diseases in Egyptian children. Egyptian Pediatric Association Gazette 2014; 62(2): 35?40.
  4. Banhidy F, Acs N, Puho EH, and Czeizel AE. Congenital abnormalities in the offspring of pregnant women with type 1, type 2, and gestational diabetes mellitus: a population based case-control study. Congenit Anom Kyoto 2010; 50:115?121.
  5. Bassili A, Mokhtar SA, Dabous NI, Zaher SR, Mokhtar MM and Zaki A. Congenital heart disease among school children in Alexandria, Egypt: An overview of prevalence and relative frequencies.J Trop Pediatr.2000; 46:357?362.
  6. Becker SM, Al Halees Z, Molina C, and Paterson RM. Consanguinity and congenital heart disease in Saudi Arabia.AmJ Med Genet 2001; 99:8?13.
  7. Blomberg MI and Kallen B. Maternal obesity and morbid obesity: the risk for birth defects in the offspring. Birth Defects Res A Clin Mol Teratol 2010; 88:35?40.
  8. Botto LD, Mulinare J, and Erickson JD. Do multivitamin or folic acid supplements reduce the risk for congenital heart defects Evidence and gaps. Am J Med Genet 2003; 121:95?110.
  9. Caton AR, Bell EM, Druschel CM, Werler MM, Lin AE, Browne ML, McNutt LA, Romitti PA, Mitchell AA, Olney RS and Correa A. Antihypertensive medication use during pregnancy and the risk of cardiovascular malformations 2009; 54:63?70.
  10. CDC,(2016) congenital heart diseases(CHDs) https://www.cdc.gov/ncbddd/heartdefects/atrialseptaldefect.html Accessed at 19/1/2017.
  11. Elizabeth D Agabegi; Agabegi, Steven S. (2008). Step-Up to Medicine (Step-Up Series). Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 0-7817-7153-6.
  12. Faheem Ul Haq, Fatima Jalil, Saman Hashmi, Maliha Iqbal Jumani, Aamer Imdad, Mehnaz Jabeen, Javad Tauseef Hashmi, Furqan Bin Irfan, Muhammad Imran, and Mehnaz Atiq. Risk factors predisposing to congenital heart defects Ann Pediatr Cardiol. 2011; 4(2): 117?121.
  13. Hoffman JI, Kaplan S, Liberthson RR, Prevalence of congenital heart disease. American Heart Journal 2004; 147 425-39.
  14. Jenkins KJ, Correa A, Feinstein JA, Botto L, Britt AE, Daniels SR, Elixson M, Warnes CA and Webb CL, American Heart Association Council on Cardiovascular Disease in the Y: Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 2007; 115:2995?3014.
  15. Khalid Y, Mumtaz G, Bitar F, Chamseddine F, Kassar M. Rashidi J, Makhoul G, and Tamim H. Consanguineous Marriage and Congenital Heart Defects For the National Collaborative Perinatal Neonatal Network (NCPNN-- American Journal of Medical Genetics Part A 2006; 140A:1524?1530.
  16. Mazen I, Amin H, Kamal A and El Ruby M. "Homozygous Mutation of the FGFR1 Gene AssociatedWith Congenital Heart Diseases and 46 XY Disorder of Sex Development" Departments of Clinical Genetics, Medical Molecular, Human Cytogenetics and National Research Center in Cairo Egypt 2016; 10: 16-22.
  17. Tandon A, Sengupta S, Shukla V and Danda Curr. Res. J. Biol. Sci., 2010, 2(4): 253-258.
  18. Webb GD, Smallhorn JF, Therrien J, and Redington AN. Congenital heart disease. In: Bonow RO, Man DL, Zipes DP, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine Philadelphia, Pa: Saunders Elsevier; 2011; 9:714-833.

[Khaled Hussein M.I. El dessouki and Mohamed Ahmed Bahaa el-deen. (2018); MATERNAL CHRONIC DISEASES AS RISK FACTOR OF CYANOTIC HEART DEFECTS (FALLOT TETRALOGY & PDA) AMONG CHILDREN IN MALLAWY CITY. Int. J. of Adv. Res. 6 (Sep). 502-508] (ISSN 2320-5407). www.journalijar.com

KHALED HUSSEIN M. EL DESSOUKI
Department of Public health and preventive medicine, Faculty of Medicine, Minia University, Egypt.

DOI:

Article DOI: 10.21474/IJAR01/7703      
DOI URL: https://dx.doi.org/10.21474/IJAR01/7703

Download Full Paper

Download PDF No. of Downloads: 8 | No. of Views: 45