Breast Cancer: Molecular Subtype Tumor Microenvironment and CD8+ Tumor Infiltrative Lymphocytes

The immune response to cancer development may be defined by the tumor infiltrating lymphocytes. Nevertheless, their significant association remains controversial in breast cancer. This study conducted to assess CD8 infiltrating rate differences among the molecular subtypes. Sixty-one cases as patients group and seven have been selected as normal group for the study. IHC was used to evaluate the expression of ER, PR, Her2\neu and CD8. ER, PR and Her2\neu were used for the molecular subtyping. CD8 assessed by H-SCORE system in two locations (intratumoral and stromal). CD8 shows no significant differences in intratumoral lymphocytes and stromal lymphocytes scores among molecular subtypes (p=.322 and =.151 respectively). There is no differences in the tumor infiltrating rate of CD8+ T-lymphocytes among the molecular subtypes.