CHONDROBLASTOMA IN THE DISTAL FEMUR: A CASE REPORT WITH LITERATURE REVIEW.

  • Departement of anatomy pathology, Mohammed VI University Hospital , Marrakech, Morocco.
  • Departement of radiology, Mohammed VI University Hospital , Marrakech, Morocco.
  • Departement of traumotalogy orthopedic, Mohammed VI University Hospital , Marrakech, Morocco.
  • Abstract
  • Keywords
  • References
  • How to Cite This Article
  • Corresponding Author

Chondroblastoma is an aggressive tumor of bone with the capacity for recurrence and metastasis with a relatively high incidence in older children and adolescents during the period of active epiphyseal growth. It is generally regarded as a benign neoplasm, but sometimes it grows aggressively or recurs.14-year-old young boy operated operated twice for chondroblastoma. Currently he presented with right knee joint pain, which started two months ago. Radiography and magnetic resonance imaging studies of the right knee showed concluded to recurrence of chondroblastoma of the distal femur. The histologic study of the biopsy curettage showed a chondroblastic with large polygonal cells. The final diagnostic was chondroblastoma.Chondroblastoma is a rare primary bone tumor of young people that typically arises in the ends of the long bonesRadiologic investigations show a small, circumscribed, lytic lesion. The tumor is characterized histologically by the proliferation of chondroblasts along with areas of mature cartilage, giant cells, and occasionally, secondary aneurysmal bone cyst formation. Recently, immunohistochemical stains such as DOG1 and SOX9 have been described in Chondroblastoma.


  1. Akhtar, S. Qadri, P. Sen Ray et al;? Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist; BMJ Case Rep 2014. doi:10.1136/bcr-2014-204178
  2. Lambert, T. Verstraeten, K. Mermuys; Chondroblastoma: An Unusual Cause Of Shoulder Pain In Adolescence; Journal of the Belgian Society of Radiology, 100(1): 16
  3. Miyazaki, K. Uchida, et al; Chondroblastoma of the distal femur resectedthrough a small fenestra via computedtomography navigation and endoscopy: a case
  4. Report; Journal of Medical Case Reports 2013, 7:164
  5. Angelini1, M. Hassani, F. Andreas. Et al; Chondroblastoma in adult age; Eur J OrthopSurgTraumatol; Received: 8 April 2017 / Accepted: 16 June 2017
  6. Ghekiere, E.Geusens, L. Lateur et al?;Chondroblastoma of the patella with a secondary aneurysmal bone cyst; Eur. Radiol. 8, 992?995 (1998)
  7. Chen, Lisa M. DiFrancesco et al?; Chondroblastoma?; Arch Pathol Lab Med?Vol 141, June 2017
  8. Brandolini, L. Bertolaccini, A. Pardolesi et al?; Chondroblastoma of the rib in a 47-year-old man: a case report with a systematic review of literature; J Thorac Dis 2017;9(10):E907-E911
  9. Kilpatrick SE, Parisien M, Bridge JA. Chondroblastoma. In: Fletcher CDM, Unni KK, Mertens F, eds. World health organization classification of tumours: pathology and genetics of tumours of soft tissues and bone. Lyon: IARC press, 2013:241?2.
  10. Ghekiere, E.Geusens, L. Lateur et al?;Chondroblastoma of the patella with a secondary aneurysmal bone cyst; Eur. Radiol. 8, 992?995 (1998)
  11. Ozkoc G, Gonlusen G, Ozalay M, et al. Giant chondroblastoma of the scapula with pulmonary metastases. Skeletal Radiol 2006;35:42?8.
  12. Yang, W. Tian , Xi. Zhu and al; Chondroblastoma in the long bone diaphysis: a report of two cases with literature review. Chin J Cancer; 2012; Vol. 31 Issue 5.
  13. Wolfe M, Halvorson T, Bennett J, Martin P (1995) Chondroblastoma of the patella presenting as knee pain in an adolescent. Am J. Orthop 24: 61
  14. Monda LWMR. S-100 protein immunostaining in the differential diagnosis of chondroblastoma. Hum Pathol 1985;16:287?93.
  15. Ramappa AJ LFYI, Tang P, Carlson JR, et al. Chondroblastoma of Bone. J Bone Joint Surg Am 2000; 82:1140?5.
  16. Huvos, RC.? Marcove, RA. Erlandson, et al.?;Chondroblastoma of bone. A clinicopathologic and electron microscopic study. Cancer, 1972,29:760-771.
  17. Turcotte RE, Kurt AM, Sim FH, et al. Chondroblastoma. Hum Pathol, 1993,24:944-949.
  18. A-M . Kurt, KK. Unni, FH. Sim, et al; Chondroblastoma of bone. Hum Pathol. 1989;20(10):965?976.
  19. Clapper, BR. DeYoung, Chondroblastoma of the femoral diaphysis: report of a rare phenomenon and review of literature. Hum Pathol 2007;38:803-6.
  20. Akpalo, C.? Lange, J.? Zustin. Discovered on gastrointestinal stromal tumour 1 (DOG1): useful immunohistochemical marker for diagnosing chondroblastoma. Histopathology. 2012; 60(7):1099?1106.
  21. Sjogren, C. Orndal, O. Tingby, et al. Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumours. Int J Oncol, 2004,24:1385-1391.
  22. Ostrowski ML, Johnson ME, Truong LD, et al. Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of
  23. Skeletal Radiol, 1999,28:644-650.
  24. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, eds. WHO Classification of Tumours of Soft Tissue and Bone. 4th ed. Lyon, France: IARC Press; 2013:240. World Health Organization Classification of Tumours; vol 5.

S. Amouzoune, s. Berrada, m. Dref, h. El mansouri, n. E. Guennouni, a. Abdelaoui, a. Benhima, h. Saidi, a. Fakhri and h. Rais. (2018); CHONDROBLASTOMA IN THE DISTAL FEMUR: A CASE REPORT WITH LITERATURE REVIEW., Int. J. of Adv. Res., 6 (11), 985-989, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/8085


S. Amouzoune
Mohammed VI University Hospital , Marrakech, Morocco

DOI:


Article DOI: 10.21474/IJAR01/8085      
DOI URL: https://dx.doi.org/10.21474/IJAR01/8085