Vol. 7 (04) pp. 565-568 DOI: 10.21474/IJAR01/8854

A STUDY OF SERUM TSH AND CORTISOL LEVELS IN PREECLAMPSIA.

  • Senior Demonstrator, Department of Biochemistry, J.L.N Medical College, Ajmer.
  • Senior Professor & Head, Department of Biochemistry, J.L.N Medical College, Ajmer.
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Abstract

Aim: The study was carried out to estimate TSH and Cortisol level in preeclamptic women as compare to normotensive women. Material and Methods: The present study has been conducted on 100 preeclampticprimigravidae in their trimester of pregnancy attending O.P.D of janana hospital, J.L.N Medical college Ajmer. 50 healthy primigravidae of similar age group were included in the study, as the control group. Results:In this study we observed that out of 100 patients of preeclampsia in which 82 patients were of mild preeclampsia and 18 patients were of severe preeclampsia. There was significant decrease in level of cortisol in patients of mild and severe preeclampsia. Decrease in level of cortisol was more in severe preeclamptics as compared to mild preeclamptic patients. There was significant increase in level of TSH in mild preeclampsia whereas more increase in severe preeclampsia. Conclusion:In this present study of 100 patients we concluded that from the results all these parameters play an important role in preeclampsia hence the measurement of TSH and cortisol activity may be used in early diagnosis and management of patients of preeclampsia. This can also be useful in assessing the severity of preeclampsia.

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References

  1. Abalovich M, Gutierrex S, Alcaraz G, Maccallini G, Garcia A, Levalle O. Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 2002 ; 12: 63-68
  2. Basbug M, Aygen E, Tayyar M, Tutus A, KayaE, Oktem O. Correlation between maternal thyroid function tests and endothelium in pre eclampsia. ObstetGynecol 1999;94:551-555
  3. Bodnar LM, Ness RB, Markovic N, Roberts JM. The risk of preeclampsia rises with increasing prepregnancy body mass index.AnnEpidemiol 2005;15:475-482
  4. Bowen CB, QiuC . Oxidative stress in preeclampsia. ActaObstetGynecolscand 2001;80:719-725
  5. Carey b m, DasheJS, wells CE, McIntire DD, Byrd EW, Leveno KJ. Subclinical hypothyroidism and pregnancy outcomes. ObstetGynecol 2005;105:239-245
  6. Divyasardana, Smitinanda, Simmikharb. Thyroid hormones in pregnancy and pre eclampsia. Turkish journal gynecol association 2009;10:168-171
  7. Dhananjaya BS, kumaran DS, venkatesh G, Murthy N, Shashiraj H. Thyroid stimulating hormone level as a possible indicator of pre eclampsia. Journal of clinical and diagnostic research 2011;5:1542-1543
  8. Franklyn J A. The management of hyperthyroidism. N Engl. J. Med 1994;330:1731-17
  9. Pregnancy in chronic renal insufficiency and end stage renal disease.Am J Kidney Dis. Feb 1999;33:235-252
  10. Khaliq F, Singhal, Z Arshad and M MHossain. Thyroid functions in pre eclampsia and its correlation with maternal age, severity of blood pressure and serum albumin. Indian journal PhysioPharmacol 1999; 43: 193-198
  11. Kopelman J.J and Levitz M. Plasma cortisol level and cortisol binding in normal and pre eclamptic pregnancies. American Journal Obstet. Gynec.1970; 108:925-930
  12. Kumar A, Ghosh B. K and Murthy N S. Maternal thyroid hormonal status in pre eclampsia. Indian Journal med. Sci 2005;59:57-63
  13. Kaya E, Sahin y, Ozkececi, Z and Pasaoglu, H. Relation between birth weight and thyroid function in pre eclampsia-eclampsia. Gynaecol.Obstet. Invest.37.1994;30-33
  14. Kaya E, Sahin Y, Ozkceci Z, Pasaoglu H. Relation between birth weight and thyroid function in preeclampsia. GynecolObstet Invest 1994;37:30-33
  15. Kaplan M.M. Management of women on thyroxine therapy during pregnancy. Endocr. Pract. 1996;2:281.
  16. Lao TT, Chin RK, Swaminathan R, Lam YM. Maternal thyroid hormones and outcome of preeclamptic pregnancies. An Int. Journal ObstetGynaecol 1990;97:71-74
  17. Larijini B, Marsoosi v, Aghakhani S, Moradi A and Hashemipour S. Thyroid hormone alteration in pre eclamptic Gynecol. Endocrinol 2004; 18:97-100
  18. Lafayette RA, Druzin M, Sibley R. Nature of glomerular dysfunction in pre eclampsia. Kidney International 1998;54:1240-1249
  19. Merchant SJ and Davidge ST. The role of matrix metalloproteinases in vascular function: implication for normal pregnancy and pre eclampsia. Br Journal obstetGynecol 2004;111:931-939
  20. Manjunatha S. Thyroid dysfunction in pregnancy and pre eclampsia. Scholars journal of applied medical sciences 2014;2:3297-3299
  21. Muzammil S, Khayyam UK, Siddiqui N ali. Serum protein ratio in normal and preeclamptic women of primiparous and multiparous in relation to age. International Journal Basic Appl Med Sci 2014;4:331-335
  22. Nobuaki Furuhashi, Hideaki Kono. Serum cortisol levels in pregnancy Induced Hypertension Patients. Tohoku J exp. Med, 1986; 149:21-24
  23. PalanisamyPasupati, P Rani. Evaluation of serum lipids and Thyroid Hormone changes in non pregnant, pregnant and pre eclampsia Woman. Thyroid science 2009;10:1-6
  24. Pruyn S c, Phelan j.p and Buchanan G. C. Long term propranolol therapy in pregnancy. Maternal and fetal outcome. Assoc. Med. Journal Obstet Gynecol. 1979;135:485-489
  25. Qublan HS, Al-kaisi IJ, Hindawi IM, Hiasat MS, Awamleh I. Severe preeclampsia and maternal thyroid function. Journal Obstet Gynecol. 2003; 23:244-246
  26. Rahul R. chaudhary. A study of thyroid profile and serum albumin in preeclampsia woman. International J cur res rev 2016;8:23-24
  27. Rajappa M, Sen SK. Evaluation of Thyroid hormone status after acute mayocardial infarction in South Indians. Biomedical Research 2005;16:15-18
  28. Rahman M H., Chowdhury, M.A and Alam, M.T. Serum thyroxine and triiodothyronine levels in normal pregnancy and preeclampsia.TAJ 2007;20:06-10
  29. Robert JM, Hubel CA. Recent insight into the pathogenesis of preeclampsia.Placenta 2002;23:359-372
  30. Sonalsogani, vandanaverma, purnimadevsarkar. Estimation of thyroid hormones levels in preeclamptic pregnant woman; an early predictor of the disease. Al amen j med science 2015;8:266-270.

How to Cite This Article

Tarique aziz and G.G Kaushik. (2019); A STUDY OF SERUM TSH AND CORTISOL LEVELS IN PREECLAMPSIA., Int. J. of Adv. Res., 7 (04), 565-568, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/8854

Corresponding Author

Dr. TARIQUE AZIZ
SENIOR DEMONSTRATOR J.L.N MEDICAL COLLEGE AJMER