Vol. 7 (03) pp. 581-589 DOI: 10.21474/IJAR01/8675

CLINICAL AND IMMUNOHISTOCHEMICAL EVALUATION OF THE EFFECT OF PROPOLIS ON ORAL LICHEN PLANUS.

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  • Lecturer of Oral Medicine, Oral Diagnosis and Periodontology, Faculty of Dentistry, Minia University, Egypt.
  • Lecturer of Oral and Maxillofacial Pathology, Faculty of Dentistry, Minia University, Egypt.
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Abstract

Aim: To evaluate the possible effects of Propolis on atrophic-erosive form of oral lichen planus. Study design: The study was conducted on 20 patients with atrophic-erosive oral lichen planus. The patients were selected from the out patients clinic of the Oral Medicine, Oral Diagnosis, and Periodontology Department, Faculty of Dentistry, Minia University, Egypt. Methodology: the 20 patients were classified into two groups? Group A: treated by 0.1% topical triamcinolone acetonide paste and Group B: treated by 5% Propolis. Each patient was monitored every 2 weeks for 8 weeks. The objective and subjective clinical progress were assessed using the Clinical Score and Visual Analog Scale. Biopsies were taken at baseline and after 8 weeks of treatment and stained immunohistochemically for tranforming growth factor-?1. Results: There was significant improvement in all clinical outcomes within the follow up periods when compared with the baseline (P <0.05). A non-significant difference was found between both studied groups at the end of week 8 in terms of VAS and CS scores (P?0.05). Immunhistochemical evaluation revealed a significant reduction in transforming growth factor ?1expression in both groups (P<0.05) while a non-significant difference was found between the studied groups (P?0.05). Conclusions: Propolis can be used as an alternative therapy for treatment of oral lichen planus.

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How to Cite This Article

Ahmed Abdallah Khalil and Enas Alaa Eldin Abd El-Aziz. (2019); CLINICAL AND IMMUNOHISTOCHEMICAL EVALUATION OF THE EFFECT OF PROPOLIS ON ORAL LICHEN PLANUS., Int. J. of Adv. Res., 7 (03), 581-589, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/8675

Corresponding Author

Enas Alaa Eldin Abd El-Aziz
Lecturer of Oral Medicine, Oral Diagnosis and Periodontology, Faculty of Dentistry, Minia University.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.