PROTECTIVE ROLES OF VITAMIN E TOWARD FORMALDEHYDE INDUCE DAMAGE IN FEMALE ALBINO MICE

  • Department of Histology and Medical Genetics , Faculty of Medicine, University of Tripoli, LIBYA
  • Department of Pharmacology and Clinical Pharmocy , Faculty of Pharmacy, University of Tripoli, LIBYA
  • Zoology Department , Science Faculty - University of Tripoli, LIBYA
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The etiology of female infertility can be broken down into ovulation disorders uterine abnormalities, tubal obstruction, and peritoneal factors, cervical factors are also thought to play a minor role. Vitamin E is a fat-soluble antioxidant that stops the production of Reactive oxygen species (ROS) formed when fat undergoes oxidation; it may prevent or delay the chronic diseases associated with free radicals .The present study was designed to investigate the protective roles of antioxidants as vitamin E toward formaldehyde induce damage in female reproductive system. Female mice (n=50, 25-40 gm) were mated, every five female mice with one male mouse for 6 days for breeding. On the sixth day, female mice were divided into five groups: group 1 (control) administered tween 80 (5 ml/kg) for 5 days, group 2 received formaldehyde (30 mg/kg) for 5 days, group 3 received vitamin E (100mg/kg) for 5 days, group 4 administered formaldehyde and vitamin E (prophylactic) for 5 days, group 5 received formaldehyde for 5 days followed by vitamin E for another 5 days (curative). At the end of 21 days, animals were sacrificed; ovaries and uterus were removed and fixed in 10% formalin solution for routine histological techniques. Intraperitoneal administration was adopted in this study. Results: it was found that formaldehyde induced reproductive and developmental toxicities result in precipitous pathologies affecting female reproduction; Vitamin E is well accepted as nature\'s most effective lipid-soluble, chain-breaking antioxidant, protecting cell membranes from free- radical mediated per oxidative damage. It can be concluded that formaldehyde causes toxicity in female reproductive system. Vitamin E repair and treat formaldehyde toxicity. The improvement induced by vitamin E was more significant in treated group compared with prophylactic group

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[Soad A. Treesh, Medeha T. Elghedamsi, Suhera M. Aburawi, Habiba A. El Jaafari, Marwa A. Shneba, Mawada M. Elfellan and Naema Shibani (2019); PROTECTIVE ROLES OF VITAMIN E TOWARD FORMALDEHYDE INDUCE DAMAGE IN FEMALE ALBINO MICE Int. J. of Adv. Res. 7 (Nov). 280-288] (ISSN 2320-5407). www.journalijar.com

Soad A. Treesh
Department of Histology and Medical Genetics, Faculty of Medicine, University of Tripoli, LIBYA.

DOI:

Article DOI: 10.21474/IJAR01/10005      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10005

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