TO STUDY GLYCEMIC STATUS AND LIPID FRACTIONS IN SUBCLINICAL HYPOTHYROID, OVERT HYPOTHYROID AND HYPERTHYROID SUBJECTS

Background:Thyroid function disorders lead to changes in the lipoprotein metabolism. Glycation is the process of non enzymatic addition or insertion of sugar to protein. Aims & Objective: The aim of this study was to find out relationship of glycemic status and lipid fractions with subclinical hypothyroid, overt hypothyroid and hyperthyroid subjects. Methodology: The present study was conducted on 100 overt hypothyroid, subclinical hypothyroid and hyperthyroid patients attending the Medical OPD and Radio Immuno Assay (RIA) Laboratory of the Biochemistry Department of JawaharLal Nehru Medical College & Hospital, Ajmer. The results of patients were compared with 50 healthy control subjects of either sex of similar age group. Results: All the lipid fraction were comparable to those of studied groups and they were significantly deranged, as compared to those of Group-I. The mean serum fructosamine (FA) level was observed statistically highly significant (p<0.001) in Group-II and Group-III and vice versa in the Group –IV subjects. Conclusion: This study indicates that monitoring of lipid in patients with thyroid dysfunction would be helpful in preventing cardiovascular diseases. The fructosamine values which are largely in excess of the fasting plasma glucose (FPG) and glycatedhaemoglobin (HbA1c) values, indicate a higher propensity to glycation and a decrease turnover of the proteins in the overt hypothyroid and the subclinical hypothyroid subjects,vice versa is true of the hyperthyroid subjects.