27May 2019

A PROSPECTIVE STUDY ON ANTIBIOTIC TRENDS IN ACUTE FEBRILE ILLNESS.

Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Aims And Objectives:The present study aims to document the antibiotics used in Acute febrile illness. 1. To identify the different antibiotics used in acute febrile illness. 2. To find out the epidemiology of antibiotics and their combination in diagnosed condition. 3. To find out the epidemiology of co morbid condition. 4. Patient knowledge after counseling. Method:An observational, prospective cohort study was conducted at a tertiary care teaching hospital in Hyderabad, T.S, India. A total of 200 patients from the inpatient department of general medicine in Aware Global Hospital, who were prescribed antibiotics and those who fulfilled the exclusion and inclusion criteria were selected for the study which was conducted for 6 months. All information significant to the study was collected from the case records and discussions conducted with the in-patients and bystanders during ward rounds, with the support of a physician, which were analyzed by SPSS and Chi-square method. Moreover, daily follow-ups were conducted to assemble data on amendment in therapy, add-on therapy, and clinical improvement. Results:The mean age was 41years and standard deviation was 18years of this population. 57% were males and 43% were females. The main demographic characteristics, co-morbidities, diagnosis and treatment are taken. The most common treatment used is Monocef (ceftriaxone) -34% and Magnex forte (cefperazone+sulbactam) -28%. They belongs to the class of 3rd generation Cephalosporin. Combination of antibiotics like Magnex forte + Azee 6% and Monocef + Azee 12% were most commonly used combinations. In the population 19.5% with hypertension(htn), 3.5% with diabetes mellitus(dm), 6%with hypertension and diabetes mellitus, 11.5% with combinations and 59.5% with no comorbidities were observed. Conclusion:The study was conducted to review and analyze different trends of antibiotics used in individuals suffering from AFI(Acute Febrile Illness). During our study, it was observed that Dengue and Respiratory tract infections were most commonly cause of AFI (Acute Febrile Illness). Monocef (ceftriaxone) and Magnex forte (cefperazone+sulbactam) belonging to the class of 3rd generation Cephalosporin weremost commonly used antibiotics. During the study it was found that majority of the patients were without co-morbidities and were within the age limit of 15-30years. In the patients who were suffering from AFI with comorbidities majority of them had hypertension and DM-type 2.

  1. Ahmed Siddiqui, Tanaji R. Shende, Y. Dhoble, Archana S. Borkar; Antibiotic trends in acute febrile illness;2003;6;334-37
  2. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report (MMWR)Global Health??Division of Parasitic Diseases and Malaria
  3. Joseph T. DiPiro, chapter 50; Urinary tract? infection; Pharmacotherapy Handbook Seventh Joseph T .dipiro; pharmacotherapy handbook;7th edition(2009);pg no:544
  4. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators;Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990?2015: a systematic analysis for the Global Burden of Disease Study 2015;Lancet 2016:388(10053);1545-1602.
  5. Foxman, Betsy; Epidemiology of Urinary Tract Infections: Incidence, Morbidity, and Economic Costs;2003;49(2);53-70
  6. Joseph T. DiPiro, chapter 25; Viral hepatitis; Pharmacotherapy Handbook Seventh edition; Joseph T .dipiro; pharmacotherapy handbook;7th edition(2009);pg no:273
  7. Chung M Chow, Alexander KC Leung, and Kam L Hon;Acute gastroenteritis: from guidelines to real life;2010;3;97-112.
  8. Fauci, Anthony ; chapter 26 ;fever of unknown origin; McGraw-Hill Professional Harrison's Principles of Internal Medicine 19th Edition. pp. 135
  9. Samir Bhatt, Peter W. Gething, and Simon I. Hay;The global distribution and burden of dengue;2013;496(7446);504-507
  10. Olaf Hoffman and R. Joerg Weber;Pathophysiology and Treatment of Bacterial Meningitis;2009;2(6);1-7.
  11. Horwood PF, Buchy P;Chikungunya;2015;34(2);479-489.
  12. KK, Dahlgren FS, Drexler NA, Dumler JS, et al. Diagnosis and management of tickbornerickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosisUnited States. MMWR Recomm Rep. 2016;65(2):1?44.
  13. Corinne N. Thompson, Stuart D. Blacksell, Daniel H. Paris, AmitArjyal, AbhilashaKarkey, Sabina Dongol, AbhishekGiri, Christiane Dolecek, Nick Day, Stephen Baker, Guy Thwaites, Jeremy Farrar, and Buddha Basnyat;Undifferentiated Febrile Illness in Kathmandu, Nepal;2015;50(4);875-878.
  14. Olga D. Lorenzi, Christopher J. Gregory, Luis Manuel Santiago, He ?ctor Acosta, Ivonne E. Galarza, Saint Luke?s Acute Febrile Illness Investigation Team; Acute Febrile Illness Surveillance in a Tertiary Hospital Emergency Department: Comparison of Influenza and Dengue Virus Infections; 2013;88(15);472?480
  15. Pui-Ying Iroh Tam, Stephen K. Obaro and Gregory Storch; Challenges in the Etiology and Diagnosis of Acute Febrile Illness in Children in Low- and Middle Income Countries;2016;5;190-205
  16. Khety Z, Mohanta GP, Patvardhan S, Jain S. Studies on Antimicrobial Consumption in a Tertiary Care Private Hospital, India. IJPPR. 2016;6(1).
  17. Dipmala Das1, Banti Das1, Asitava Deb Roy and T. S. K. Singh1; Common Infectious Etiologies of Acute Febrile Illness in a Remote Geographical Location: Could Scrub Typhus be the Most Common Cause?; 2015; 10(10): 1-10.
  18. Fauci, Anthony ; chapter 23;Fever; McGraw-Hill Professional Harrison's Principles of Internal Medicine 17th Edition(2008). pp. 123-125
  19. Evans SS, Repasky EA, Fisher DT . "Fever and the thermal regulation of immunity: the immune system feels the heat". Nature Reviews Immunology. 15 (6): 335?349
  20. Fauci, Anthony; chapter 147; Basic considerations in infectious diseases; McGraw-Hill Professional. Harrison's Principles of Internal Medicine ;17th edition;pp. 779-784
  21. Chapter 13: infectious diseases: Textbook of Davidson's Principles & Practice of Medicine, 22nd Edition. P. 299. Table no 13.4,13.5
  22. Harrisons ; chapter 85;Diagnosis of Infectious Diseases; harrisons manual of medicine ;18th edition;p.485
  23. Harrisons ;section 2; cardinal manifestation and assessment of disease ;harrisons principles of internal medicine ;19th edition;p.126
  24. Chapter 13: infectious diseases: Textbook of Davidson's Principles & Practice of Medicine, 22nd Edition. P. 295
  25. harrisons ;chapter 34;Fever, Hyperthermia and Rash; harrisons manual of medicine ;18th edition;p.210
  26. John A Crump, associate professor of medicine and pathology, Sandy Gove, team leader, and Christopher M Parry, senior clinical consultant; Management of adolescents and adults with febrile illness in resource limited areas;2011;343.
  27. Joseph T .dipiro ,Cecily V .dipiro ;chapter 50; urinary tract infections and prostatitis ;In. Joseph T .dipiro; pharmacotherapy handbook;7th edition(2009);p.544-555
  28. Roger Walker; chapter 37; gastrointestinal infections ;Clinical Pharmacy and Therapeutics;5th edition ;P-573-583.
  29. Chapter 13: infectious diseases: Textbook of Davidson's Principles & Practice of Medicine, 22nd Edition. P. 307.
  30. joseph t.dipiro, Cecily v.dipiro; chapter 43; respiratory tract infections lower ;In.josepht.dipiro; pharmacotherapy handbook;7th edition(2009);p.465-477.
  31. Harrisons ;chapter 97 ;Meningococcal and Listerial Infections; Harrisons manual of medicine ;18th edition;P.603-608.
  32. Roger Walker; chapter 38; Infective meningitis;Clinical Pharmacy and Therapeutics;5th edition ;P-584-595.
  33. Roger Walker; chapter 35; respiratory infections ;Clinical Pharmacy and Therapeutics;5th edition ;P-545-565.
  34. Roger Walker; chapter 14; constipation and diarrhoea ;Clinical Pharmacy and Therapeutics;5th edition ;P-209-221.
  35. Koda-Kimble. Chapter 93: paediatric considerations. In; Brian K editors. Textbook of Koda-Kimble and Young's Applied Therapeutics -The Clinical Use of Drugs, 10th Edition (2013). P.93.
  36. Nguyen ThanhHung ,Department of Dengue Hemorrhagic Fever;Fluid management for dengue in children;2012 ;32 ;p.39-41.
  37. dipiro, Cecily v.dipiro ;chapter 39 ;gastrointestinal infections ; In.josepht.dipiro; pharmacotherapy handbook;7th edition(2009);p.434.
  38. Roger Walker; chapter 37; gastrointestinal infections ;Clinical Pharmacy and Therapeutics;5th edition ;P-573-583.
  39. Guidelines for treatment of dengue fever/dengue haemorrhagic fever in small hospitals. New Delhi, India: World Health Organization, 1999.
  40. EmilieJavelle,AnneRibera,IsabelleDegasne,BernardAlexGa?z?re,CatherineMarimoutou,FabriceSimon; Specific Management of Post-Chikungunya Rheumatic Disorders :A Retrospective Study of 159 Casesin Reunion Island from2006-2012
  41. Joseph T .dipiro ,Cecily V .dipiro ;chapter 43; respiratory tract infections upper ;In. Joseph T .dipiro; pharmacotherapy handbook;7th edition(2009);p.478-486.
  42. John A Crump, associate professor of medicine and pathology, Sandy Gove, team leader, and Christopher M Parry, senior clinical consultant;Management of adolescents and adults with febrile illness in resource limited areas; 2011; 343.
  43. WHO- Vector Disease Control International-malaria http://www.vdci.net/vector-borne-diseases/malaria-education-and-integrated-mosquito-management-to-protect-public-health.
  44. Chapter 23:Liver and biliary tract disease: Textbook of Davidson's Principles & Practice of Medicine, 22nd Edition. P. 922-986.
  45. Joseph T .dipiro ,Cecily V .dipiro ; chapter 112; gastrointestinal infections and enterotoxigenic poisonings ;In. Joseph T .dipiro; pharmacotherapy A pathophysiologic approach ;7th edition(2009);p.1857-1873
  46. Ahmed Al-Badr1 and Ghadeer Al-Shaikh2; Recurrent Urinary Tract Infections Management in Women ; 2013, Vol. 13, pp. 359-367.
  47. Joseph T .dipiro ,Cecily V .dipiro ; chapter 112; upper respiratory tract infections ;In. Joseph T .dipiro; pharmacotherapy A pathophysiologic approach ;7th edition(2009);p.1779-1790.
  48. G K Pal Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research;Effective management and prevention of dengue fever; 2015 ;Vol 2 ;P.148-150.
  49. Abdul Zahir, MPhil;1 AsadUllah, PhD;1 Mussawar Shah, PhD;1 Arsalan Mussawar2;Community Participation, Dengue Fever Prevention and Control Practices in Swat, Pakistan;(2015), 5, No. 1, 39-45.
  50. KamarajuRaghavendra ,Tapan K., Barik, B. P. Niranjan Reddy, Poonam Sharma, AdityaP.Dash; Malaria vector control: from past to future;2011;108 (4); pp 757?779.
  51. Dr David G Lalloo, Dr David G Lalloo, PejuOlukoya MD, PieroOlliaro MD; Malaria in adolescence: burden of disease, consequences, and opportunities for intervention;2006,6(12)p780?793.
  52. Mehlhorn H, ed.;"Disease Control, Methods". Encyclopedia of Parasitology (3rd ed.). Springer. 2008,pp. 362?6.
  53. Tickell-Painter, M; Maayan, N; Saunders, R; Pace, C; Sinclair, D; "Mefloquine for preventing malaria during travel to endemic areas". The Cochrane Database of Systematic Reviews;2017; 10.
  54. Freedman DO ; "Clinical practice. Malaria prevention in short-term travelers"; New England Journal of Medicine;2008; 359 (6): 603?12.
  55. J P Geetha, MV Rashmi, NiranjanMurthy ;Acute Febrile Illness with Thrombocytopenia-a Common Scenario ; 2015 ;6(4) ;163.
  56. Rani RA, Sundararajan T, Rajesh S, Jeyamurugan T. A Study on Common Etiologies of Acute Febrile Illness Detectable by Microbiological Tests in a Tertiary Care Hospital. Int. J. Curr. Microbiol. App. Sci. 2016;5(7):670-4.
  57. Chitra B. Study on utilization pattern of antibiotics at a private corporate hospital. Indian Journal of Drugs. 2016;4(15):69-74.
  58. Kundavaram Paul PrabhakarAbhilash, Jonathan Arul Jeevan,and George M Varghese; Acute Undifferentiated Febrile Illness in Patients Presenting to a Tertiary Care Hospital in South India: Clinical Spectrum and Outcome ; 2016;8(4);147-154.
  59. Das D, Das B, Roy AD, Singh TSK. Common Infectious Etiologies of Acute Febrile Illness in a Remote Geographical Location: Could Scrub Typhus be the Most Common Cause? British Journal of Medicine and Medical Research. 2015;10(10):1-10.
  60. Saleh N, Awada S, Jibai S, Arfoul C, Zaiter L, et al. evaluation of antibiotic prescription in the Lebanese community: a pilot study. Infection ecology and epidemiology; 2015;5.
  61. Meher BR, Mukherjee D, Uday Shankar. A study on antibiotic utilization pattern in a general medicine ward of a tertiary care teaching hospital. Journal of Chemical and Pharmaceutical Research. 2014;6(7):1847-9.
  62. Ahmad A, Revanker M, Haque I, Pravina A, Ivan R, Dasari R, et al. Study the Prescription Pattern of Antibiotics in the Medicine Department in a Teaching Hospital: A Descriptive Study. International Journal of Toxicological and Pharmacological Research. 2014;6(2):43-6.
  63. Chandy SJ, Thomas K, Mathai E, Antonisamy B, Kathleen A. Holloway 6 and Cecilia Stals by Lundborg Patterns of antibiotic use in the community and challenges of antibiotic surveillance in a lower-middle-income country setting: A repeated cross-sectional study in Vellore, south India. J. Antimicrobic. Chemotherapy. 2013;68(1):229-36.
  64. Tina M. Parker,Concurrent Infections in Acute Febrile Illness Patients in Egypt; 2007,77(2); pp. 390?392

[Dhannarapu Priyanka, N. Sravyareddy, ManishaVazeer, G. Siri Chandana and Amatul Ali Sameera. (2019); A PROSPECTIVE STUDY ON ANTIBIOTIC TRENDS IN ACUTE FEBRILE ILLNESS. Int. J. of Adv. Res. 7 (May). 1060-1090] (ISSN 2320-5407). www.journalijar.com

Ms. Dhannarapu Priyanka,

DOI:

Article DOI: 10.21474/IJAR01/9136      
DOI URL: https://dx.doi.org/10.21474/IJAR01/9136

Download Full Paper

Download PDF No. of Downloads: 35 | No. of Views: 220