Vol. 7 (05) pp. 405-409 DOI: 10.21474/IJAR01/9052

STUDY OF ENDOTHELIAL DYSFUNCTION IN TYPE 1 DIABETES MELLITUS USING DOPPLER ULTRASOUND.

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  • Professor, Department of Medicine R.N.T. Medical College, Udaipur, Rajasthan(India).
  • Post-Graduate Resident, Department of Medicine R.N.T. Medical College, Udaipur, Rajasthan(India).
  • Sr. Professor, Department of Medicine R.N.T. Medical College, Udaipur, Rajasthan(India).
  • Sr. Resident,Department of Medicine R.N.T. Medical College, Udaipur, Rajasthan(India).
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Abstract

Introduction:Microvascular diabetic complications are the most common causes of morbidity and mortality in patients with type 1 DM. The main etiology for mortality and a great percent of morbidity in patients with diabetes mellitus is atherosclerosis. A hypothesis for the initial lesion of atherosclerosis is endothelial dysfunction Aim:This study aims to evaluate the incidence of endothelial dysfunction in type 1 DM in relation to glycaemic control , duration of disease and other factors using Doppler ultrasound. Methods:A prospective case control study was conducted on 50 type 1 DM cases and 50 matched controls over a period of one year from January 2018 to December 2018 using colour doppler ultrasonography of brachial artery. Results:It was observed that among the 50 type 1 DM , endothelial dysfunction was (FMD<10%) present among 19 (38%) cases and 1 (2%) controls. Macroalbuminuria as measured by urine ACR was present in 3 cases (6%) of type1 DM while none of the controls had macroalbuminuria. Microalbuminuria was present in 13 cases (26%) and 4 controls (8%). Diabetic Retinopathy was noted in 7 cases of Type 1 DM (14%) and all of them had endothelial dysfunction. Conclusion:Endothelial dysfunction was seen in all duration of diabetes (<5, 5-10, >10 years) and prevalence increased with duration of diabetes. Identification of endothelial dysfunction early in the course of Type 1 DM, it may be possible to delay the development of microvascular and macrovascular complications, ultimately reducing the morbidity of the disease.

How to Cite This Article

Hemant Mahur, Ayush Jain, D.P. Singh, Jerin Romeo, Chandraprakash Mudgal and Chinmay Hegde. (2019); STUDY OF ENDOTHELIAL DYSFUNCTION IN TYPE 1 DIABETES MELLITUS USING DOPPLER ULTRASOUND., International Journal of Advanced Research (IJAR), 7 (05), 405-409, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/9052

Corresponding Author

Dr. Ayush Jain
Post Graduate Resident

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