25May 2019

DEVELOPMENT AND OPTIMIZATION OF BI LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE.

  • PG Department of Pharmaceutics, Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar.
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Objective:To optimize and develop Bi layered floating tablet (SFMS) containing ulcer protective Sucralfate as immediate release layer and anti hypertensiveMetoprolol Succinate as sustained release layer. Method: 15 formulations of Sucralfate and 10 formulations of Metoprolol Succinate is taken. By changing the concentration of Superdisintigrant, Surfectants, Alkalizing agents & Binding agents of Sucralfate and changing concentrations of Alkalizing agents and Polymers of Metoprolol Succinate the OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) is generated.. Result: Within 5 minutes in acidic medium , 7% Superdisintigant (Crosspovidone), 7% Surfectant (Polysorbate-80), 15% Alkalizing agents(Sodium bicarbonate), 5% HPC (Binding agent) averagely produce 68.56%drug release. Within 20 hours in acidic medium , 30% Alkalizing agents(Sodium bicarbonate) , 50% Soluablepolymer (HPMC K) ,40% Polymer (Udragid RSPO, 35% HPC Polymer(NaCMC), 30% Polymer (Sodiumalginate) ,25% Polymer (HPC) , 20% Polymer, Udragid RS), 5% HPC Polymer (PVPK) produce averagely100.06% drug release. Conclusion:The optimized formulation 400 mg tablet weight of OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) produce better result and identified as better formulation for further studies.

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[Sreedhar Ranjan Das, Bibhuti Bhusan Panigrahi And Manoj Kumar Pani. (2019); DEVELOPMENT AND OPTIMIZATION OF BI LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE. Int. J. of Adv. Res. 7 (May). 832-849] (ISSN 2320-5407). www.journalijar.com

Mr Sreedhar Ranjan Das
Research scholar

DOI:

Article DOI: 10.21474/IJAR01/9105      
DOI URL: https://dx.doi.org/10.21474/IJAR01/9105

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