03Jul 2019

GC-MS BASED METABOLIC PROFILE OF BRAIN TISSUE IN COMMON CARP FOLLOWING ACUTE EXPOSURE TO CYPERMETHRIN.

  • Education and Research Center for Marine Resources and Environment, Faculty of Fisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima 890-0056, Japan.
  • Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, University of Mansoura, Mansoura, 35516, Egypt
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In the current study, the GC-MS metabolomics analysis was employed to explain the neurotoxic effect of cypermethrin on the metabolic profile in the brain of carp fish. The carps exposed to two concentrations of cypermethrin (0.1 and 1 ?g/L) for 24 and 96 hours. The levels of glutamate, tryptophan, tyrosine, glutamine and histidine showed marked increase, while levels of GABA and glycine were decreased compared to control group. Additionally, cypermethrin significantly reduced the level of glucose at 24 h suggesting a disruption in energy production with subsequent usage of lactate as an energy source. Collectively, the present work is the first that proposes a possible mechanism of cypermethrin neurotoxicity in carp fish and reflects the risk of cypermethrin existence in an aquatic environment.

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[Ola Ali Habotta, Mamdouh Mohamed Abouelmagd, Amal Abdelmonem Halawa and Seiichi Uno. (2019); GC-MS BASED METABOLIC PROFILE OF BRAIN TISSUE IN COMMON CARP FOLLOWING ACUTE EXPOSURE TO CYPERMETHRIN. Int. J. of Adv. Res. 7 (Jul). 188-194] (ISSN 2320-5407). www.journalijar.com

olahabotta
Mansoura University

DOI:

Article DOI: 10.21474/IJAR01/9344      
DOI URL: https://dx.doi.org/10.21474/IJAR01/9344

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