Effect of Betamethasone dipropionate, Betamethasone valerate and combination of Betamethasone valerate and Neomycin sulphate with Biopolymer on skin inflammatory model in Wistar rats

Topical anti-inflammatory agents are used to treat muscle pains, sprains, strains and arthritis. Topical anti-inflammatory agents are sometimes prescribed instead of oral anti-inflammatory agents because they have lesser side-effects. Hence there is always a need for better topical anti-inflammatory drugs. A study was undertaken to compare the efficacy of betamethasone dipropionate with biopolymer with betamethasone dipropionate (Betamil) and betamethasone valerate with biopolymer with betamethasone valerate (Betnovate) and combination of betamethasone valerate and neomycin sulphate with biopolymer with betamethasone valerate and neomycin sulphate (Betnovate N) in croton oil ear edema model in rats. There was significant reduction in edema for all the treatment groups when compared with the control group (p < 0.001).