MANAGEMENT OF ANTIDEPRESSANT INDUCED SIDE EFFECTS.
- Assistant Professor, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560029, Karnataka, India.
- Associate dean and Chairperson Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Sciences, Ras Khaimah, P.O.Box 11172. United Arab Emirates.
52 Downloads
154 Views
Abstract
Over the last two decades, the safety and acceptability of antidepressants have been enhanced considerably. However, the adverse effects due to antidepressants are still challenging. Majority of the antidepressants cause annoying side effects when prescribed to patients with depression. These side effects often form hurdles to achieving remission of depressive episodes. Quite often the frequency of side effects are underestimated and nearly 25% of patients discontinue their treatment because of hard-to-accept adverse effects; others may continue on medication but experience reduced quality of life due to worrying adverse effects.
Proper controlling of adverse effects improves adherence, warrants suitable dosing, increases patient well-being and stops early termination of therapy. Suitable management comprises thoughtful drug assortment, expectation of common and rare but serious adverse effects and attempting for the lowest effective dose and simplest drug schedules reliable with appropriately robust management.
Keywords
Article Analytics
References
- Andrade, C., Sandarsh, S., Chethan, K. B., & Nagesh, K. S. (2010). Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms. The Journal of clinical psychiatry, 71(12), 1565-1575.
- Bahrick, A. S. (2008). Persistence of sexual dysfunction side effects after discontinuation of antidepressant medications: Emerging evidence. The Open Psychology Journal, 1(1).
- Carvalho, A. F., Sharma, M. S., Brunoni, A. R., Vieta, E., & Fava, G. A. (2016). The safety, tolerability and risks associated with the use of newer generation antidepressant drugs: a critical review of the literature. Psychotherapy and psychosomatics, 85(5), 270-288.
- Clayton, A. H., Pradko, J. F., Croft, H. A., Montano, C. B., Leadbetter, R. A., Bolden-Watson, C., Metz, A. (2002). Prevalence of sexual dysfunction among newer antidepressants. The Journal of clinical psychiatry.
- Coker, F., & Taylor, D. (2010). Antidepressant-induced hyperprolactinaemia. CNS drugs, 24(7), 563-574.
- Demyttenaere, K., Enzlin, P., Dewe, W., Boulanger, B., De Bie, J., De Troyer, W., & Mesters, P. (2001). Compliance with antidepressants in a primary care setting, 1: beyond lack of efficacy and adverse events. Journal of Clinical Psychiatry, 62, 30-33.
- Demyttenaere, K., & Jaspers, L. (2008). Bupropion and SSRI-induced side effects. Journal of Psychopharmacology, 22(7), 792-804.
- Hoehn-Saric, R., Lipsey, J. R., & McLeod, D. R. (1990). Apathy and indifference in patients on fluvoxamine and fluoxetine. Journal of clinical psychopharmacology.
- Hu, X. H., Bull, S. A., Hunkeler, E. M., Ming, E., Lee, J. Y., Fireman, B., & Markson, L. E. (2004). Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimate. The Journal of clinical psychiatry, 65(7), 959-965.
- Kelly, K., Posternak, M., & Jonathan, E. A. (2008). Toward achieving optimal response: understanding and managing antidepressant side effects. Dialogues in clinical neuroscience, 10(4), 409.
- Kennedy, S. H., & Rizvi, S. (2009). Sexual dysfunction, depression, and the impact of antidepressants. Journal of clinical psychopharmacology, 29(2), 157-164.
- Kinrys G., Simon NM., Farach FJ., Pollack MH. Management of antidepressant- induced side effects. In: Alpert JE, Fava M, eds. . Handbook of Chronic Depression. New York, NY: Marcel Dekker, Inc. 2004:411?446.
- La Torre, D., & Falorni, A. (2007). Pharmacological causes of hyperprolactinemia. Therapeutics and Clinical Risk Management, 3(5), 929.
- Marcy, T. R., & Britton, M. L. (2005). Antidepressant-induced sweating. Annals of Pharmacotherapy, 39(4), 748-752.
- Matreja, P. S., Badyal, D. K., Deswal, R. S., & Sharma, A. (2012). Efficacy and safety of add on low-dose mirtazapine in depression. Indian journal of pharmacology, 44(2), 173.
- Mondal, S., Saha, I., Das, S., Ganguly, A., Das, D., & Tripathi, S. K. (2013). A new logical insight and putative mechanism behind fluoxetine-induced amenorrhea, hyperprolactinemia and galactorrhea in a case series. Therapeutic advances in psychopharmacology, 3(6), 322-334.
- Montejo-Gonzalez, A. L., Llorca, G., Izquierdo, J. A., Ledesma, A., Bouso o, M., Calcedo, A., De la Gandara, J. (1997). SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. Journal of Sex and Marital Therapy, 23, 176-194.
- Montejo, A. L., Llorca, G., Izquierdo, J. A., & Rico-Villademoros, F. (2001). Incidence or sexual dysfunction associated with antidepressant agents: A prospective multicenter study of 1022 outpatients. The Journal of clinical psychiatry.
- Nelson, J. C. (1997). Safety and tolerability of the new antidepressants. The Journal of clinical psychiatry, 58, 26-31.
- Nurnberg, H. G., Hensley, P. L., Heiman, J. R., Croft, H. A., Debattista, C., & Paine, S. (2008). Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial. Jama, 300(4), 395-404.
- Papakostas, G. I., Miller, K. K., Petersen, T., Sklarsky, K. G., Hilliker, S. E., Klibanski, A., & Fava, M. (2006). Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. The Journal of clinical psychiatry, 67(6), 952-957.
- Papakostas, G. I. (2007). Limitations of contemporary antidepressants: tolerability. The Journal of clinical psychiatry, 68, 11-17.
- Renoir, T. (2013). Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved. Frontiers in pharmacology, 4, 45.
- Rothschild, A. J. (1995). Selective serotonin reuptake inhibitor-induced sexual dysfunction: efficacy of a drug holiday. The American journal of psychiatry.
- Sinclair, L. I., Christmas, D. M., Hood, S. D., Potokar, J. P., Robertson, A., Isaac, A., ... & Davies, S. J. (2009). Antidepressant-induced jitteriness/anxiety syndrome: systematic review. The British Journal of Psychiatry, 194(6), 483-490.
- Uguz, F. (2013). Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. The Journal of Maternal-Fetal & Neonatal Medicine, 26(11), 1066-1068.
- Depression In: Organization WH, (ed), 2017.
- Wang, S. M., Han, C., Bahk, W. M., Lee, S. J., Patkar, A. A., Masand, P. S., & Pae, C. U. (2018). Addressing the side effects of contemporary antidepressant drugs: a comprehensive review. Chonnam medical journal, 54(2), 101-112.
- Wouters, H., Van Dijk, L., Van Geffen, E. C. G., Gardarsdottir, H., Stiggelbout, A. M., & Bouvy, M. L. (2014). Primary-care patients' trade-off preferences with regard to antidepressants. Psychological medicine, 44(11), 2301-2308.
- Wouters, H., Bouvy, M. L., Van Geffen, E. C., Gardarsdottir, H., Stiggelbout, A. M., & Van Dijk, L. (2014). Antidepressants in primary care: patients? experiences, perceptions, self-efficacy beliefs, and nonadherence. Patient preference and adherence, 8, 179.
- Zajecka, J., Tracy, K. A., & Mitchell, S. (1997). Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a literature review. The Journal of clinical psychiatry, 58:291-297.
- Zajecka, J. (2001). Strategies for the treatment of antidepressant-related sexual dysfunction. The Journal of clinical psychiatry, 62, 35-43.
How to Cite This Article
Bhavya K Bairy and Laxminarayana K Bairy. (2019); MANAGEMENT OF ANTIDEPRESSANT INDUCED SIDE EFFECTS., Int. J. of Adv. Res., 7 (08), 242-246, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/9496
Corresponding Author
This work is licensed under a Creative Commons Attribution 4.0 International License.





