ROLE OF SHATAVARI IN MANAGEMENT OF EARLY OSTEOARTHRITIS.
- Associate Professor, Department of Biochemistry, LokmanyaTilak Municipal Medical College & Hospital, Sion Mumbai.
- Assistant Professor, Department of Biochemistry, LokmanyaTilak Municipal Medical College & Hospital, Sion Mumbai.
- Professor & Head, Department of Biochemistry, LokmanyaTilak Municipal Medical College & Hospital, Sion Mumbai.
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- Corresponding Author
Introduction:Osteoarthritis (OA) is most common form of progressive and degenerativejoint disease that results from breakdown of joint cartilage and underlying bone. It has been one of the primary causes of morbidity in elderly population, affecting their social and mental health due to the pain associated with degeneration. Vitamin D plays important role in calcium and phosphorus homeostasis, which in turn are responsible for strength of bones & cartilages. ALP is an enzymatic marker for bone metabolism, levels being predominantly increased in osteoblastic activity . Although there are multiple causes of osteoarthritis, deficiency of vitamin D, hypocalcemia & hypophosphatemia are predominantly responsible for pathophysiology of osteoarthritis. It is also characterized by increased ALP activity. Shatavari(Asparagus racemosa Linn) is considered to have antioxidant, anti-inflammatory, immunomodulator, soothing, cooling, and lubricating influence on the body. In the present study effect of shatavari in patients of early osteoarthritis have been studied. Aim &Objectives:Clinical& biochemical evaluation of early osteoarthritis patients before & after Shatavari treatment. Material and methods: 30 patients of early osteoarthritis were clinically evaluated by orthopedic consultant by pain score and mobility of joints. Baseline blood sample was collected for estimation of S. Calcium, Phosphorus, ALP and Vit D. All patients were treated with Shatavari (Formulation prepared by ayurvedic medical college & hospital) at dosage of 3 gms OD for 2 months. Clinical & biochemical evaluation were repeated 15 days after the last dose of shatavari. Results: Result obtained were statistically analyzed by using paired t test. Post treatment analysis of samples showed significant (p<0.05) increase in Calcium ,Vitamin D and decrease in Alkaline phosphatase levels whereas difference in serum phosphorus was statistically insignificant. Conclusion: It can be concluded thatShatavari treatment has beneficial effect on the patients of early Osteoarthritis& should be included as a routine treatment in management of such patients.
- Feelisch M. The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis. Osteoarthritis Cartilage. 2008;16Suppl 2:S3-S13.
- Woolf A. D., Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;81(9):646-56.
- ShuckettMannal Hasan; Rhonda. Clinical features and pathogenetic mechanism of osteoarthritis. BC Medical Journal. 2010;52(8):6.
- Golub EE. Role of matrix vesicles in biomineralization. BiochemBiophysActa. 2009; 1790: 1592-8.
- McAlindon T,?LaValley M,?Schneider E,?Nuite M,?Lee JY,?Price LLetal. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA.?2013 Jan 9;309(2):155-62.
- Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc.?2006 Mar;81(3):353-73.
- Gomase V and Sherkhane A: Isolation, structure elucidation and biotransformation studies on secondary metabolites from Asparagus racemosus. Int J Microbiol Res 2010; 2:7-9.
- Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial. Rheumatology 2013;52:1408-17.
- Subramoniam A, Madhavachandran V, Gangaprasad A. Medicinal plants in the treatment of arthritis. Annals of Phytomedicine 2013;2: 3-36.
- Claudia M Witt, Michalsen A , Roll S, Morandi A, Gupta S. Comparative effectiveness of a complex Ayurvedic treatment and conventional standard care in osteoarthritis of the knee-study protocol for a randomized controlled trial, Trials 2013;14:149.
- Tietz, N., Clinical Guide to Laboratory Tests, W.B. Saunders Company, Philadelphia 3rded 1983; 5: 384.
- Z Klin. ChemKlin Biochem.1980;8:658.
- Tietz N.W. Clinical Guide?on?Laboratory Tests.?W.B. Saunders Company, Philadelphia 3rded1995;286.
- Dynal AS. Access 25(OH) Vitamin D TOTAL Assay Package Insert, REF B24838, Oslo, Norway C06543AA.
- Bassiouni H, Aly H, Zaky K, Abaza N, Bardin T. Probing the relation between vitamin D deficiency and progression of medial femoro-tibialosteoarthitis of the knee. Ann Rheum Dis. 2015;74:368-9.
- Veronese N, Maggi S, Noale M, et al. Serum 25-hydroxyvitamin D and osteoarthritis in older people: the Progetto Veneto Anziani study. Rejuvenation Res. 2015;18:543-53.
- Jansen JA, Haddad FS. High prevalence of vitamin D deficiency in elderly patients with advanced osteoarthritis scheduled for total knee replacement associated with poorer preoperative functional state. Ann R CollSurg Engl. 2013;95:569-72.
- Konstari S, Kaila-Kangas L, Jaaskelainen T. Serum 25- hydroxyvitamin D and the risk of knee and hip osteoarthritis leading to hospitalization: a cohort study of 5274 Finns. Rheumatology. 2014;53:1778-1782.
- Malas FU? , Kara M, Aktekin L, Erso?z M, O? zc? akar L. Does vitamin D affect femoral cartilage thickness? An ultrasonographic study. ClinRheumatol. 2014;33:1331-4.
- Zhang FF, Driban JB, Lo GH . Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014;144: 2002-8.
- Heidari B, Heidari P, Hajian-Tilaki K. Association between serum vitamin D deficiency and knee osteoarthritis. IntOrthop. 2011;35: 1627-31.
- Goula T, Kouskoukis A, Drosos G. Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country. J OrthopTraumatol. 2015;16:35-39.
- Van Staa?TP, Geusens?P, Bijlsma?JW, Leufkens?HG, Cooper?C. Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum 2006;54:3104-12.
- Manrique?F, Gamardo?J, Elguezabal?K, Martinis?R, Castro?JS, Bellorin-Font?E,?et?al.?Abnormalities of bone mineral density and bone metabolism in Venezuelan patients with rheumatoid arthritis. J?ClinRheumatol 2003;9:219-27.
- Singla R and Jaitak V: Shatavari (Asparagus racemosus Wild): A review on its cultivation, morphology, phytochemistry and pharmacological importance. Int J Pharm Sci Res 2014; 5(3): 742-57.
[Pooja S.K.Rai, Kanchan Sonone and Pramod Ingale. (2019); ROLE OF SHATAVARI IN MANAGEMENT OF EARLY OSTEOARTHRITIS. Int. J. of Adv. Res. 7 (Sep). 460-464] (ISSN 2320-5407). www.journalijar.com
Article DOI: 10.21474/IJAR01/9684
DOI URL: http://dx.doi.org/10.21474/IJAR01/9684
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