GLYPHOSATE AND PENDIMETHALIN IN BREAST MILK SAMPLES FROM EGYPTIAN RURAL AREAS: A PILOT STUDY FOR INFANTS RISK ASSESSMENT.
- Mammalian & Aquatic Toxicology Department, Central Agricultural Pesticides Laboratory (CAPL), Agricultural Research Center (ARC), 12618-Dokki, Giza, Egypt.
- Department of Plant Protection, Faculty of agriculture, Damanhur University, 22516-Damanhur, Egypt.
- Pesticide Residues & Environmental Pollution Department, Central Agricultural Pesticides Laboratory (CAPL), ARC, 12618-Dokki, Giza, Egypt.
- Abstract
- Keywords
- References
- How to Cite This Article
- Corresponding Author
Thirty-one samples of breast milk were collected from some rural mothers and conducted for herbicides; glyphosate and pendimethalin analysis followed by their impact on infants. Three rural locations; Shobrakhite, Abo Homos and Abo El-Matamir in El-Behira governorate were selected for the study as well as an urban location in Alexandria as a reference. Glyphosate and pendimethalin exhibited ranges of concentrations; 3.25-27.91; below detection limit-8.91; below detection limit-10.11 ?g/ml and 1.44-21.62; 2.51-15.94; 1.88-24.02 ?g/ml for Shobrakhite, Abo Homos and Abo El-Matamir locations, respectively. High vegetables and cereal consumption by mothers showed higher herbicide-contaminated milk (r=0.273* and 0.24*) than others. On the other hand, herbicides were negatively associated with young and house wife individuals (r=-0.272* and -0.330*). Tolerable daily intakes for infants were addressed for rank of low, moderate and high exposure. Infants of Abo El-Matamir location exhibited the greatest value for pendimethalin, but group of Shobrakhite location exhibited the greatest value for glyphosate. The present findings indicate that, signs alarms of adverse health effects of herbicides may be imposed on these infants and their families.
- Amiliato N., Ammar D., Nezzi L., et al. (2014): Changes in ultrastructure and expression of steroidogenic factor-1 in ovaries of zebra fish Danio rerio exposed to glyphosate. J. Toxicol. Environ. Health Part A 77: 405-414.
- APC (2007): Agricultural Pesticides Committee, Pesticide Annual Report, Ministry of Agriculture, Egypt.
- Bouwman H., Sereda B., and Meinhardt H.M. (2006): Simultaneous presence of DDT and pyrethroid residues in human milk from a malaria endemic area in South Africa. Environ. Pollut. 144(3): 902-917.
- Burke E.R., Holden A.J. and Shaw I.C. (2003): A method to determine residue levels of persistent organochorine pesticides in human milk from Indonesian women. Chemosphere 50: 529.
- Cohort Software Inc. (1985):Costat User Manual. Version 3 Cohort Tucson, Arisona, USA.
- Diserens H. and Henzelin M. (1999): Determination of abamectin residues in fruits and vegetables by high performance liquid chromatography. J. Chromatography A 833: 13-18.
- EPA (2015): Pendimethalin; Pesticide Tolerances. EPA-HQ-OPP-2014-0397 (https://wwwregulations gov/docket?D=EPA-HQ-OPP-2014-0397).
- European Community (2003): Review report for the active substance pendimethalin. Report 7477/VI/98-final. European Commission, Health and consumer protection Directorate General, Brussels, Belgium.
- Feo M.L., Eljarrat E., Manaca M.N., et al. (2012): Pyrethroid use-malaria control and individual applications by households for other pests and home garden use. Environ. Int. 38 (1): 67-72.
- Gasnier C., Dumont C., Benachour N., et al. (2009): Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicol. 262: 184-191.
- Guyton K.Z., Loomis D., Grosse Y., et al. (2015): Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon and glyphosate. Lancet. Onco. 16: 490-501.
- Halperin-Walega E., Batra V.K., Tonlli A.P., Barr A. and Yacobi A. (1998): Disposition of cefixime in the pregnant and lactating rat transfer of the fetus and nursing pups. Drug Metab. Dispost. 16: 130-138.
- Heifetz R.M. and Taylor S.S. (2015): Mother?s milk or mother?s poison? Pesticides in breast milk. J. Pestic. Reform 1-6 http://eap megill ca/MagRack/JPR/JPR_07 htm.
- IARC (2015): Glyphosate monograph some organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos http://monographs iracfr/ENG/Monographs/vol112/mono112-09 pdf.
- Jensen A.A. and Slorach S.A. (1991): Chemical contaminants in human milk. Boca Raton, FI: CRC Press, 1991.
- Kataoka H. (2005): Gas chromatography of amines as various derivatives. Quantitation of amino acids and amines by chromatography-methods and protocols. J. Chromatography 70: 364-404.
- Khalil F., Ouda S., Osman N.A. and Ghamis A. (2011): Determination of agro-climatic zones in Egypt using a robust statistical procedure. 15th Int. Water Technol. Conf. (IWTC), Alexandria 2011, Egypt.
- Lakritz I. and Pensabene J.W. (1984): Survey of human milk for volatile N-nitrosamines and the influence of diet on their formation. Food Chem. Toxicol. 22: 721-724.
- Manaca M.N., Grimalt J.O., Sunyer J., et al. (2011): Concentration of DDT compounds in breast milk from African women (Manhica, Mozambique) at the early stages of domestic indoor spraying with this insecticide. Chemosphere 85 (3): 307-314.
- Matthews H.B. (1979): Excretion of Insecticides. Pharmac. Ther. 4: 657.
- Moza P.N., Huster S., Pal S. and Sukul P. (1992): Photocataltic decomposition of pendimethalin and alachlor. Chemosphere 25(11): 1675-1682.
- Myers J.P., Antoniou M.N., Blumberg B., et al. (2016): Concerns over use of glyphosate-based herbicides and risks associated with exposure: a consensus statement. Environ. Health 15(19): 13.
- Palma D.C.A., Lourencetti C., Uecker M.E., Mello P.R.B., Pignati W.A. and Dores E.F.G. (2014): Simultaneous determination of different classes of pesticides in breast milk by solid-phase dispersion and GC/ECD. J. Braz. Chem. Soc. 25(8): 1419-1430.
- Pignati W.A., Machado J. and Cabral J.F. (2007): Major rural accident: The pesticide ?rain? case in Lucas do Rieverde city-MT. Cienc. &SaudeColetiva 12(1): 105-114.
- Romano M.A., Romano R.M., Santos L.D., et al. (2012): Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression. Arch. Toxicol. 86: 663-673.
- Sewell B.H. and Whyatt R.M. (1989): Intolerable risk: Pesticides in our children?s food New York: Natural Resources Defense Fund.
- Sonawane B.R. (1995). Chemical contaminants in human milk: an overview. Environ. Health Perspect. 103 (6): 197-205.
- Steinborn A., Alder L., Michalski B., Zomer P., Bendig P., et al. (2016): Determination of glyphosate levels in breast milk samples from Germany by LC-MS/MS and GC-MS/MS. J. Agric. Food Chem. 64: 1414-1421.
- Thier H.P. and Zeumer H. (1987): Manual of Pesticide Residue Analysis. VerlagChemie: New
- Thongprakaisang S., Thiantanawat A., Rangkadilok N., et al. (2013): Glyphosate induces human breast cancer cell growth via estrogen receptors. Food Chem. Toxicol. 59: 129-136.
- Walsh L.P., Mc Cormick C., Martin C., et al. (2000): Round up inhibits steroidogenesis by disrupting steriodogenic acute regulatory (StAR) protein expression. Environ. Health Prespect. 108: 769-776.
Khaled Y. Abdel-Halim, Mohamed A. F. Abuzeid, Fayza A. Seddik and Alaa M. Khozimy. (2019); GLYPHOSATE AND PENDIMETHALIN IN BREAST MILK SAMPLES FROM EGYPTIAN RURAL AREAS: A PILOT STUDY FOR INFANTS RISK ASSESSMENT., Int. J. of Adv. Res., 7 (09), 991-1002, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/9747
Mammalian & Aquatic Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center (ARC), Dokki, 12618, Giza, Egypt






