15Nov 2019

PREVENTION OF POST PARTUM DEPRESSION : COMPARATIVE STUDY BETWEEN SERTRALINE AND PAROXETIN

  • Assistant Professor, Department of Obst and gynae , G.S.V. M Medical college Kanpur
  • Assistant Professor Departent Of Pharmacology G.M.C Kannauj
  • Professor And Head Department Of Pharmacology G.M.C Kannauj
  • Demonstrator , Department Of Pharmacology G.M.C Kannauj
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Objective: The authors attempted to reduce the rate of postpartum depression in high-risk women and to increase the time to recurrence comparing Sertraline and Paroxetine . METHOD: Nondepressed pregnant women with at least one past episode of postpartum major depression were recruited into a randomized clinical trial. Mothers were assigned randomly to a 17-week trial of sertraline or paroxetine immediately after birth and assessed for 20 sequential weeks with the Hamilton Rating Scale for Depression. RESULTS: Of 22 subjects who took sertraline, 6 suffered a recurrence. Of 22 subjects who were assigned to paroxetine, four ) suffered recurrences. This difference was not significant. The time to recurrence was significantly equal in the sertralineand paroxetine-treated women. Conclusions: Sertraline and Paroxetine confer preventive efficacy for postpartum-onset major depression and prevent recurrence and have equal efficacy.

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[Shruti Gupta, Ch. Nagesh, Mohit Trivedi, Ambrish Kumar Gupta and Shruti Dubey (2019); PREVENTION OF POST PARTUM DEPRESSION : COMPARATIVE STUDY BETWEEN SERTRALINE AND PAROXETIN Int. J. of Adv. Res. 7 (Nov). 840-843] (ISSN 2320-5407). www.journalijar.com

Dr Shruti Gupta
Assistant Professor, Department of Obst and gynae , G.S.V. M Medical college KANPUR.

DOI:

Article DOI: 10.21474/IJAR01/10083      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10083

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