A study on antibiotic sensitivity, bacterial dissemination and humoral immunity against experimental infection of white mice with Salmonella enteridis

A local strain of Salmonella enteridisobtained from the public health laboratory, the bacterial strain reidentified to be sure S. enteridisusing cultural, biochemical test, API 20 E and slide agglutination test by Vitek test. The LD50 of this microbe was 1.4*106 CFU. This bacterial agent was sensitive to chloramphenicol, cefriaxone, ciprofloxacin,cotrimoxazole and resistant to neomycin, streptomycin and rifampicin and variable sensitivity to amoxicillin and ampicillin. S. enteridiswere disseminated into all over the organs and persisted for 2 weeks in all organs except that in liver and spleen it persisted for 27 days post inoculation. Good immune response initiated following S. enteridisexperimental infection in white mice detected by Elisa test. Conclusion: 1. S. enteridiswas sensitive to the most antibiotic and resistant to some one. 2. S. enteridisdisseminated all over the body organs of white mice. 3. S. enteridisinduce a good humoral immune response.