Serum Insulin and Leptin Levels in Chronic Renal Failure Patients Using Radiometric Techniques

As a very real and growing problem, chronic kidney disease is characterized by progressive deterioration of kidney function which develops eventually into a terminal stage of chronic kidney failure. The present study aimed at investigating the variations which may occur in some biochemical parameters in chronic kidney failure patients under haemodialysis (three times / week) compared to healthy volunteers in the same age range. The results revealed highly significant increase in serum urea, creatinine, triglyceride, insulin and leptin in patients compared to the controls. The increase of insulin levels in patients before dialysis points to the development of insulin resistance and liability to diabetes. Also the significant increases in serum leptin in patients is associated with deteriorated kidney function and decreased renal clearance of leptin