PREVALENCE OF DEPRESSION AMONG PATIENTS WITH VITAMIN D DISTURBANCE AND RESPONSE TO TREATMENT AT ARMED HOSPITALS, TAIF 2018
- Abstract
- References
- Cite This Article as
- Corresponding Author
Objectives: To measure prevalence of depression among vitamin D deficiency and insufficiency patient attending armed hospital, Taif- 2018. Methods: A cross-sectional study was implemented at Alhada Military Hospital, Taif city, Saudi Arabia included all adult patients attending family medicine clinic throughout the period Agust 1st-September 30, 2018 with either newly diagnosed vitamin D deficiency or insufficiency or on regular treatment for vitamin D disturbance. A prepared English interview checklist was used in collecting data from patient. DSM-V criteria were used for diagnosis major depression. Results: The study included 213 patients. Their age ranged between 15 and 88 years, with a mean?SD of 47.6?15.8 years. Majority of the participants had vitamin D insufficiency (81.7%) while only 18.3% of them had vitamin D deficiency. More than one-third of the participants (36.6%) were on current vitamin D treatment whereas 16.5% of them stopped treatment. The duration of vitamin D use was three months or more among 15.5% of the participants. Regarding the current dose, it was 5000 IU/week among 29.1% of the patients. Major depression was diagnosed, based on DSM-V criteria in only two patients (0.9%). Depression was present in 55.5% of the participants, based on PHQ-9 questionnaire; it was mild among 36.6% and moderately severe or severe among 6.5% of them. Vitamin D disturbance was not significantly associated with depression. Conclusions: The rate of depression is high among patients with vitamin D disturbance with no significant difference between patients with vitamin D deficiency and those with insufficiency.
- Sassan Pazirandeh M, David L Burns, MD. Overview of vitamin D. In: Kathleen J Motil M, PhD,Marc K Drezner, MD, editor. UpToDate. UpToDate, Jean E Mulder, MD. (Accessed on November 28,2017.): UpToDate.
- Marc K Drezner M. Causes of vitamin D deficiency and resistance. In: Clifford J Rosen M, editor. UpToDate. UpToDate, Jean E Mulder, MD. ( Accessed on October 23,2017): UpToDate.
- Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1, 25-dihydroxyvitamin D3, and the immune system. The American journal of clinical nutrition. 2004;80(6):1717S-20S.
- Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. SOUTHERN MEDICAL JOURNAL-BIRMINGHAM ALABAMA-. 2005;98(10):1024.
- Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1α-hydroxylase in human brain. Journal of chemical neuroanatomy. 2005;29(1):21-30.
- Lee DM, Tajar A, O?Neill TW, O?Connor DB, Bartfai G, Boonen S, et al. Lower vitamin D levels are associated with depression among community-dwelling European men. Journal of psychopharmacology. 2011;25(10):1320-8.
- Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, et al. Vitamin D, cognition, and dementia A systematic review and meta-analysis. Neurology. 2012;79(13):1397-405.
- Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. The British journal of psychiatry. 2013;202(2):100-7.
- Al Hariri A. Depression and Vitamin D Deficiency/Insufficiency among Saudis: The Relationships and Differences. Vitamins & Minerals. 2016;5:143.
- Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. New England Journal of Medicine. 1997;337(10):670-6.
- Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. Bmj. 2003;326(7387):469.
- American Psychiatric Association. Diagnostic and statistical manual of mental disorders,. 5th, (DSM-5). ed. Washington, DC: American Psychiatric Publishing; ; 2013.
- Spedding S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014;6(4):1501-18.
- Giordano N, Goracci A, Fagiolini A. Depression and Vitamin D deficiency: Causality, assessment, and clinical practice implications. Neuropsychiatry. 2017;7(5):606?14.
- de Oliveira C, Hirani V, Biddulph JP. Associations between vitamin D levels and depressive symptoms in later life: evidence from the English Longitudinal Study of Ageing (ELSA). The Journals of Gerontology: Series A. 2017.
- Pu D, Luo J, Wang Y, Ju B, Lv X, Fan P, et al. Prevalence of depression and anxiety in rheumatoid arthritis patients and their associations with serum vitamin D level. Clinical rheumatology. 2018;37(1):179-84.
- Humble MB. Vitamin D, light and mental health. Journal of Photochemistry and Photobiology B: Biology. 2010;101(2):142-9.
- Kwon SI, Son JS, Kim YO, Chae CH, Kim JH, Kim CW, et al. Association between serum vitamin D and depressive symptoms among female workers in the manufacturing industry. Annals of occupational and environmental medicine. 2015;27(1):28.
- Jovanova O, Aarts N, Noordam R, Carola‐Zillikens M, Hofman A, Tiemeier H. Vitamin D serum levels are cross‐sectionally but not prospectively associated with late‐life depression. Acta Psychiatrica Scandinavica. 2017;135(3):185-94.
- Milaneschi Y, Hoogendijk W, Lips P, Heijboer A, Schoevers R, Van Hemert A, et al. The association between low vitamin D and depressive disorders. Molecular psychiatry. 2014;19(4):444.
- Jaddou H, Batieha A, Khader Y, Kanaan S, El-Khateeb M, Ajlouni K. Depression is associated with low levels of 25-hydroxyvitamin D among Jordanian adults: results from a national population survey. European archives of psychiatry and clinical neuroscience. 2012;262(4):321-7.
- Bani-Issa W, Eldeirawi K, Harfil S, Fakhry R. Vitamin D deficiency and its determinants in adults: A sample from community-based settings in the United Arab Emirates. International journal of endocrinology. 2017;2017.
- Polak MA, Houghton LA, Reeder AI, Harper MJ, Conner TS. Serum 25-hydroxyvitamin D concentrations and depressive symptoms among young adult men and women. Nutrients. 2014;6(11):4720-30.
- Sotodehasl N, Malek F, Tamadon MR. Vitamin D Deficiency and Depression: A Short Review Article. Middle East Journal of Rehabilitation and Health. 2015;2(3).
- Batieha A, Khader Y, Jaddou H, Hyassat D, Batieha Z, Khateeb M, et al. Vitamin D status in Jordan: dress style and gender discrepancies. Annals of Nutrition and Metabolism. 2011;58(1):10-8.
- Gaikwad M, Vanlint S, Moseley GL, Mittinty MN, Stocks N. Factors associated with vitamin d testing, deficiency, intake, and supplementation in patients with chronic pain. Journal of dietary supplements. 2018;15(5):636-48.
- Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer research. 2009;29(9):3713-20.
- Parker GB, Brotchie H, Graham RK. Vitamin D and depression. Journal of affective disorders. 2017;208:56-61.
- Gowda U, Mutowo MP, Smith BJ, Wluka AE, Renzaho AM. Vitamin D supplementation to reduce depression in adults: meta-analysis of randomized controlled trials. Nutrition. 2015;31(3):421-9.
- J?zefowicz O, Rabe-Jablonska J, Wozniacka A, Strzelecki D. Analysis of vitamin D status in major depression. Journal of Psychiatric Practice?. 2014;20(5):329-37.
[Dalal Siadi AL Qurashi (2019); PREVALENCE OF DEPRESSION AMONG PATIENTS WITH VITAMIN D DISTURBANCE AND RESPONSE TO TREATMENT AT ARMED HOSPITALS, TAIF 2018 Int. J. of Adv. Res. 7 (Nov). 1046-1053] (ISSN 2320-5407). www.journalijar.com
doctor