23Dec 2019

NUTRACEUTICALS: A BETTER ALTERNATIVE TO STATINS IN THE FIGHT AGAINST ATHEROSCLEROSIS - A REVIEW

  • School of Basic and Applied Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bangalore - 78, Karnataka, India
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Atherosclerosis: A major cause of death in todayes world- is an inflammatory disease resulting from high plasma concentrations of cholesterol, especially that of Low - density lipoprotein (LDL). It leads to formation of lipid laden plaques which later blocks coronary arteries leading to heart attacks. Current medications used for the treatment and prevention are statins. However, statins have dangerous neuronal side effects. Traditional System of medicine in India- Ayurveda lists medicines which also serve as food in our daily lives, hence the name Nutraceuticals: The knowledge of these Nutraceuticals is currently being integrated into therapeutic regimen, considering the serious side effects of allopathic drugs. Medicinal plants have wide range of anti-atherosclerotic compounds many of which are as yet unexplored. Many of these plants have even shown reversal of atherosclerotic plaques. The present review provides a comparison of the action of Nutraceuticals with statins and shows how statins could one day be replaced with Nutraceuticals as the major therapy for atherosclerosis.

  1. Lusis A. Atherosclerosis (2000)?Nature. 407: 233-241.
  2. Haller H (1977) Epidermiology and associated risk factors of hyperlipoproteinemia.?Zeitschrift fur die gesamteinnereMedizin und ihreGrenzgebiete32(8): 124-128.
  3. Quinn MT, Parthasarathy S, Fong LG and Steinberg D (1987) Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.?Proceedings of the National Academy of Sciences84(9): 2995-2998.
  4. Steinberg D (1997) Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem272(34): 20963-20966.
  5. Sk?l?n K, Gustafsson M, Rydberg EK, Hult?n LM, Wiklund O, Innerarity TL and Bor?n J (2002) Subendothelial retention of atherogenic lipoproteins in early atherosclerosis.?Nature417(6890): 750.
  6. Cushing SD, Berliner JA, Valente AJ, Territo MC, Navab M, Parhami F, Gerrity R, Schwartz CJ and Fogelman AM (1990) Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.?Proceedings of the National Academy of Sciences87(13): 5134-5138.
  7. Glass CK and Witztum JL (2001) Atherosclerosis: the road ahead.?Cell104(4): 503-516
  8. Libby P, Ridker PM and Maseri A (2002) Inflammation and atherosclerosis.?Circulation105(9): 1135-1143.
  9. R?os PG, Kalra AA, Wilson JD, Tanji K, Akman HO, G?mez EA, Schon EA and DiMauro S (2012) Congenital megaconial myopathy due to a novel defect in the choline kinase Beta gene.?Archives of neurology69(5): 657-661.
  10. Xu X, Li H, Hou X, Li D, He S, Wan C, Yin P, Liu M, Liu F and Xu J?(2015) Punicalagin induces Nrf2/HO-1 expression via upregulation of PI3K/AKT pathway and inhibits LPS-induced oxidative stress in RAW264. 7 macrophages.?Mediators of inflammation
  11. Penolazzi L, Lampronti I, Borgatti M, Khan MTH, Zennaro M, Piva R and Gambari R (2008) Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis.?BMC complementary and Alternative Medicine8(1): 59
  12. Senokuchi T, Matsumura T, Sakai M, Yano M, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Imoto K, Nishikawa T and Kim-Mitsuyama S (2005) Statins suppress oxidized low density lipoprotein-induced macrophage proliferation by inactivation of the small G protein-p38 MAPK pathway.?Journal of Biological Chemistry280(8): 6627-6633.
  13. DeVries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, Davis RJ, Flavell R and Tabas I (2005) Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.?J Cell Biol.?171(1): 61-73.
  14. Varshney R and Budoff MJ (2016) Garlic and heart disease.?The Journal of nutrition146(2): 416S-421S.
  15. Antony B, Merina B, Sheeba V and Mukkadan J (2006) Effect of standardized Amla extract on atherosclerosis and dyslipidemia.?Indian journal of pharmaceutical sciences68(4).
  16. Yokozawa T, Kim HY, Kim HJ, Tanaka T, Sugino H, Okubo T, Chu DC and Juneja LR (2007) Amla (Emblica officinalis Gaertn) attenuates age-related renal dysfunction by oxidative stress.? of Agricultural and Food Chemistry55(19): 7744-7752.
  17. Ruiz-Velasco N, Domı́nguez A and Vega MA (2004) Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-γ ligands Putative contribution of Rho GTPases in statin-induced CD36 expression.?Biochemical pharmacology67(2): 303-313.
  18. Tirtha S.S., The Ayurveda Encyclopedia: Natural Secrets to Healing, Prevention and Longevity, Sat Yuga Press (2007).
  19. Li J, Wang H, Shi X, Zhao L, Lv T, Yuan Q, Hao W and Zhu J (2019) Anti-proliferative and anti-migratory effects of Scutellaria strigillosa Hemsley extracts against vascular smooth muscle cells.?Journal of ethnopharmacology235:155-163.
  20. Sone H, Shimano H, Shu M, Nakakuki M, Takahashi A, Sakai M, Sakamoto Y, Yokoo T, Matsuzaka K, Okazaki H and Nakagawa Y (2004) Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.?Biochemical and biophysical research communications316(3): 790-794.
  21. Li et al (2001) Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation.?Cardiovascular research.
  22. Potapovich AI, Lulli D, Fidanza P, Kostyuk VA, De Luca C, Pastore S and Korkina LG (2011) Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR?ERK pathway.?Toxicology and Applied Pharmacology255(2): 138-149.
  23. Gao M, Ma Y and Liu D (2013)Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice.?Pharmaceutical research30(11): 2940-2950.
  24. Karki R, Park CH and Kim DW (2013) Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264. 7).?Journal of Integrative Medicine11(4): 246-252.
  25. Li C, Lun W, Zhao X, Lei S, Guo Y, Ma J and Zhi F (2015) Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells.?Mediators of inflammation.
  26. Rahman K and Lowe GM (2006) Garlic and cardiovascular disease: a critical review.?The Journal of nutrition136(3): 736S-740S.
  27. Lin XL, Hu HJ, Liu YB, Hu XM, Fan XJ, Zou WW, Pan YQ, Zhou Q, Peng MW and Gu CH (2017) Allicin induces the upregulation of ABCA1 expression via PPARγ/LXRα signaling in THP-1 macrophage-derived foam cells.?International journal of molecular medicine39(6):1452-1460.
  28. LiaoCH, Sang S, Liang YC, Ho CT and Lin JK (2004) Suppression of inducible nitric oxide synthase and cyclooxygenase‐2 in downregulating nuclear factor‐kappa B pathway by Garcinol.?Molecular Carcinogenesis: Published in cooperation with the University of Texas MD Anderson Cancer Center41(3): 140-149.
  29. LiaoCH, Sang S, Ho CT and Lin JK (2005) Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down‐regulation of Src, ERK, and Akt survival signaling in human colon cancer cells.?Journal of cellular biochemistry96(1):155-169.
  30. John OD, Brown L and Panchal SK (2019) Garcinia fruits: Their potential to combat metabolic syndrome.?Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery39-80.
  31. Mandosi E, Fallarino M, Gatti A, Carnovale A, Rossetti M, Lococo E, Buchetti B, Filetti S, Lenti L and Morano S (2010) Atorvastatin downregulates monocyte CD36 expression, nuclear NFκB and TNFα levels in type 2 diabetes.?Journal of atherosclerosis and thrombosis
  32. Terblanche M, Almog Y, Rosenson RS, Smith TS and Hackam DG (2007) Statins and sepsis: multiple modifications at multiple levels.?The Lancet infectious diseases7(5): 358-368.
  33. Sassano A and Platanias LC (2008) Statins in tumor suppression.?Cancer letters260(1-2): 11-19.
  34. Ahn, Sethi and Aggarwal (2007) Simvastatin potentiates TNF-α-induced apoptosis through the down-regulation of NF-κB-dependent antiapoptotic gene products.
  35. Rubic T, Trottmann M and Lorenz RL (2004) Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin.?Biochemical pharmacology67(3): 411-419.

[Hari Priyaa G, Sinjitha S Nambiar and Sunil S. More (2019); NUTRACEUTICALS: A BETTER ALTERNATIVE TO STATINS IN THE FIGHT AGAINST ATHEROSCLEROSIS - A REVIEW Int. J. of Adv. Res. 7 (Dec). 858-862] (ISSN 2320-5407). www.journalijar.com

Dr. Sinjitha S Nambiar
School of Basic and Applied Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bangalore –78, Karnataka, India

DOI:

Article DOI: 10.21474/IJAR01/10222      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10222

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