Androgen Receptor CAG repeat Length polymorphism Is Not Associated with the risk of Benign Prostatic Hyperplasia

Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. The androgens, particularly DHT regulate the growth of prostatic epithelial cells by binding to the androgen receptor (AR) present in nucleus. The DHT-AR complex interacts with specific target promoter sequence regulating transcription of target genes. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially influence BPH risk. We analyzed the association between CAG repeat length and risk of BPH in a case-control study of a Indian population. We evaluated 217 subjects; 128 with BPH and 89 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed by DNA sequencing followed by PCR. We have analyzed common polymorphisms in this gene in 128 BPH patients, and 89 controls. We didn’t observe the mean CAG repeats length has significant difference between cases and controls. We also categorized the data in three different form (Short<17, Moderate17-19 and Long >19), but the frequency distribution of CAG repeat was no significant between cases and controls. Also no significant difference was observed with extreme and moderate size (Extreme<17 &>19 and Moderate 17-19) between cases and controls.