ROLE OF VITAMIN D ON TREATMENT OF BRONCHIOLITIS IN CHILDREN

  • AL-Emmaman AL-kadhemain Teaching Hospital.
  • Professor, Department of Pediatric, College of Medicine, AL-Nahrain University.
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Vitamin D plays a major role in growth and development of children. Optimal levels of vitamin D in first year of life are found to be preventive for lower respiratory tract infections. Aim of Study: To assess the effect of vitamin D supplementation on treatment of bronchiolitis. Patients and methods: This study is prospective follow up study conducted in Pediatric Wards of Al-Imamain Medical city in Baghdad through the period from 1st of January, 2018 to 31st of January, 2019 on convenient sample of 200 children with bronchiolitis divided into two group .group A include 98 children who were managed by traditional treatment of bronchiolitis (oxygen ,fluid ,frequent sucking of secretion ) and V.D supplementation (400 iu)daily and group B that include 102 children managed with traditional treatment only . The vital signs and hospital stay duration of children were assessed daily . Results: No significant differences were observed between two study groups regarding demographic, social, clinical and feeding characteristics. Also no significant differences were observed regarding respiratory rate at admission and at discharge. There was a significant difference regarding heart rate at discharge (p=0.05). A significant association was observed between children with vitamin D and shorter hospital stay duration (p<0.001). Conclusions: Vitamin D supplementation is important in treatment of bronchiolitis.


  1. Esposito S, Lelii M. Vitamin D and respiratory tract infections in childhood.?BMC Infect Dis 2015; 15:487.
  2. Zittermann A, Gummert JF. Nonclassical vitamin D actions.?Nutrients?2010; 2:408?425.
  3. Saad K, Mohamed S. A trial of vitamin D supplementation in infants with bronchiolitis: a randomized, placebo-controlled study. Am J Neurosci 2014; 5:36?39.
  4. Kua KP, Lee SW. Complementary and alternative medicine for the treatment of bronchiolitis in infants: A systematic review.?PLoS One 2017; 12(2):e0172289.
  5. Behrman RE, Kleigman Rm, Jenson HB, editors. Nelson textbook of Pediatrics. Twentieth edition. Philadelphia. W. B. Saunders Company. 2015.
  6. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: A systematic analysis. The Lancet 2010; 375(9730): 1969-1987.
  7. Nair H, Simoes AF, Rudan E, Gessner BD, Azziz-Baumgartner E, Zhang JSF, et al; for the Severe Acute Respiratory Working Group. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: A systematic analysis. The Lancet 2013; 381: 1380-1390.
  8. Hampp C, Kauf TL, Saidi AS, Winterstein AG. Costeffectiveness of respiratory syncytial virus prophylaxis in various indications. Archives of Pediatric and Adolescent Medicine 2011; 165(6): 498-505.
  9. Meissner HC. Viral Bronchiolitis in Children. N Engl J Med 2016; 37:62-72.
  10. 10-Al-Janabi MK, Nadhem H, Aziz N. Epidemiological, Clinical Profiles and Outcome of Bronchiolitis in Iraqi Children. Fac Med Baghdad 2007; 49 (4): 407-413.
  11. Hamid F, Quaium SMMA, Rahman A, Ahmad ATR, Khan S, Hussain T, et al. Audit on the Management of Bronchiolitis: A Single Centre Real World Experience in Bangladesh Can We do Better? Chattagram Maa-O-Shishu Hospital Medical College Journal 2015; 14 (1): 6-10.
  12. Trefny P,?Stricker T,?Baerlocher C,?Sennhauser FH. Family history of atopy and clinical course of RSV infection in ambulatory and hospitalized infants. Pediatr Pulmonol 2004; 30(4):302-306.
  13. Farzana R, Hoque M, Kamal MS, Choudhury MU. Role of Parental Smoking in Severe Bronchiolitis: A Hospital Based Case-Control Study. International Journal of Pediatrics 2017, Article ID 9476367, 4 pages.
  14. Rida MF. Risk Factors For Respiratory Syncytial Virus (RSV) Bronchiolitis in Children. A hospital Based Study. The Iraqi Postgraduate Medical Journal 2011; 10 (3): 305-310.
  15. Lanari M,?Prinelli F,?Adorni F,?Di Santo S,?Faldella G,?Silvestri M,?et al;?Italian Neonatology Study Group on RSV Infections. Maternal milk protects infants against bronchiolitis during the first year of life. Results from an Italian cohort of newborns. Early Hum Dev?2013; 89 Suppl 1:S51-57.
  16. Hollis BW, Wagner CL. New insights into the vitamin D requirements during pregnancy.?Bone Res 2017; 5:17030.
  17. Beigelman A, Castro M, Schweiger TL, Wilson BS, Yin-DeClue H, Sajol G, et al. Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants.?J Pediatric Infect Dis Soc 2014; 4(3):182-188.
  18. alasa N,?Williams J,?Faouri S,?Shehabi A,?Vermund SH,?Wang L, et al. Natural history and epidemiology of respiratory syncytial virus infection in the Middle East: Hospital surveillance for children under age two in Jordan. Vaccine?2015; 33(47):6479-6487.
  19. Al-Sharifi ZAR, Al-Ammar HAG,?Mahmood?HG, Turki KM, Al-Karkhi II. Lack of Vitamin D in Iraqi Children with Asthma. Biomedical & Pharmacology Journal 2017; 10(1): 89-93.
  20. Rajshekhar CS, Vanaki R, Badakali AV, Pol RR, Yelamali BC. Efficacy of Vitamin D supplementation in the treatment of severe pneumonia in children aged less than five years. Int J Contemp Pediatr 2016; 3:96-99.
  21. Erol M, Kaya H, Bostan Gayret ?, Yiğit ?, Hamil?ıkan Ş, Can E. The Effect of Vitamin D Deficiency on the Severity of Bronchiolitis in Infants. J Pediatr Res 2017; 4:12-16.
  22. Morales E, Romieu I, Guerra S, Ballester F, Rebagliato M, Vioque J, et al. Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring Epidemiology 2012; 23 (1): 2364-2371.
  23. Manaseki-Holland S, Maroof Z, Bruce J, Mughal MZ, Masher MI, Bhutta ZA, et al. Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: A randomised controlled superiority trial. Lancet 2012; 379(9824):1419-1427.
  24. Saad K, Abd Aziz NHR, El-Houfey AA, El-Asheer O, Mohamed SAA, Ahmed AE, et al. Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study. Pediatric Allergy, Immunology, and Pulmonology 2015; 28 (2): 111-120.
  25. Allen KJ, Panjari M, Koplin JJ. VITALITY trial: protocol for a randomised controlled trial to establish the role of postnatal vitamin D supplementation in infant immune health. BMJ Open 2015; 5:e009377.
  26. Belderbos ME,?Houben ML,?Wilbrink B,?Lentjes E,?Bloemen EM,?Kimpen JL,?et al. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics?2011; 127(6):e1513-1520.
  27. Dotta A. Prevention of bronchiolitis from the hospital to home: enviromental and pharmacological strategies. J Pediatr Neonat Individual Med 2015; 4(2):e040242.
  28. Cediel G, Pacheco-Acosta J, Castillo-Dur?n C. Vitamin D deficiency in pediatric clinical practice. Arch Argent Pediatr 2018; 116(1):e75-e81.

[Mays Falah M.B.Ch.B, Abdul Karem Jasem Mohammed FICMS and Areej Alomran CABP (2020); ROLE OF VITAMIN D ON TREATMENT OF BRONCHIOLITIS IN CHILDREN Int. J. of Adv. Res. 8 (Feb). 600-606] (ISSN 2320-5407). www.journalijar.com


Abdul Karem Jasem Mohammed
medical college

DOI:


Article DOI: 10.21474/IJAR01/10491      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10491