11Feb 2020

GROSSESSE MOLAIRE TUBAIRE : A PROPOS DE 05 CAS ET REVUE DE LA LITTERATURE TUBAL HYDATIDIFORM MOLE: 05 CASES REPORT AND LITERATURE REVIEW

  • Service de Gynecologie Obstetrique 1, Hopital Mere Enfant - CHU Hassan 2 Fes. Maroc.
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Gestational trophoblastic disease (GTD) include a broad spectrum of diseases ranging from benign precancerous lesions, partial and complete hydatidiform mole, malignant lesions, invasive moles, choriocarcinoma and tumors of the implantation site [1]. The incidence of hydatidiform mole is 1 in 1000?2000 pregnancies. The molar tubal pregnancy is extremely rare with an incidence of approximately 1.5 per 1 000 000 births [2]. We related in our series 5 cases of a tubular hydatiform mole collected in Obstetrics and Gynecology Department 1 of the Teaching Hospital Hassan II, Fez - Morocco, for a period of 7 years from 2010 to 2017. Three patients report an infertility history, with one secondary to polycystic ovary syndrome. The patients were submitted to gynecological emergencies for bleeding with pelvic pain, and in whom the dosage of β-hCG was positive with variable rates, and whose pelvic ultrasound performed was in favor of adnexal images with effusion. The ruptured EP was evoked in four cases hence the indications for exploratory laparotomy. One laparoscopic salpingectomy was performed for an unruptured ampullary EP. Surgical exploration revealed aspect of a ruptured tubal pregnancy appearance with in one case a vesicle appearance, with non-retainable tubes indicating salpingectomies with postoperative course was uneventful. The histopathological study mentioned the diagnosis of tubal hydatiform mole. The molar biological monitoring was satisfactory in all five cases.


  1. From the Centers for Disease Control and Prevention. Ectopic pregnancy--United States, 1990-1992. JAMA. 1995;273(7):533.
  2. Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531?539.
  3. Soper JT. Gestational trophoblastic neoplasia. Curr Opin Obstet Gynecol. 1990;2(1):92?97.
  4. Nowak-Markwitz E, Drews K, Spaczyński M. [Gestational trophoblastic disease: the epidemiological analysis of 342 cases]. Ginekol Pol. 2000;71(8):767?772.
  5. Depypere HT, Dhont M, Verschraegen-Spae MR, Coppens M. Tubal hydatidiform mole. Am J Obstet Gynecol. 1993;169(1):209?210.
  6. Hertig AT. Atlas of tumor pathology. In: Atlas of tumor pathology. 1956. Washington, D.C.
  7. Bagshawe KD, Lawler SD, Paradinas FJ, Dent J, Brown P, Boxer GM. Gestational trophoblastic tumours following initial diagnosis of partial hydatidiform mole. Lancet Lond Engl. 1990;335(8697):1074?1076.
  8. Pschera H. Hydropic degeneration resembling hydatidiform mole in tubal pregnancy. Acta Obstet Gynecol Scand. 1989;68(3):275?276.
  9. Chase JS, Check JH, Nowroozi K, Wu CH. First-trimester serum levels of the beta-subunit of human chorionic gonadotropin in a tubal molar pregnancy. Am J Obstet Gynecol. 1987;157(4 Pt 1):910.
  10. Lu D, Tang JJ, Zakashansky K, Berkowitz RS, Kalir T, Liu Y. Heterotopic Pregnancy Including Intrauterine Normal Gestation and Tubal Complete Hydatidiform Mole: A Case Report and Review of the Literature. Int J Gynecol Pathol Off J Int Soc Gynecol Pathol. 2017;36(5):428?432.
  11. Burton JL, Lidbury EA, Gillespie AM, Tidy JA, Smith O, Lawry J, et al. Over-diagnosis of hydatidiform mole in early tubal ectopic pregnancy. Histopathology. 2001;38(5):409?417.
  12. Candelier J-J. The hydatidiform mole. Cell Adhes Migr. 2016;10(1?2):226?235.
  13. Chalmers JA. Hydatidiform mole in the fallopian tube. J Obstet Gynaecol Br Emp. 1948;55(3):322?324.
  14. Adli AG. Hydatidiform mole in the fallopian tube. Int Surg. 1976;61(2):84?85.
  15. Gillespie AM, Lidbury EA, Tidy JA, Hancock BW. The clinical presentation, treatment, and outcome of patients diagnosed with possible ectopic molar gestation. Int J Gynecol Cancer Off J Int Gynecol Cancer Soc. 2004;14(2):366?369.

[Rahaoui Mohamed, Zizi Hamza, Mamouni Nisrine, Errarhay Sanae, Bouchikhi Chahrazed and Banani Abdelaziz (2020); GROSSESSE MOLAIRE TUBAIRE : A PROPOS DE 05 CAS ET REVUE DE LA LITTERATURE TUBAL HYDATIDIFORM MOLE: 05 CASES REPORT AND LITERATURE REVIEW Int. J. of Adv. Res. 8 (Feb). 1256-1262] (ISSN 2320-5407). www.journalijar.com


RAHAOUI Mohamed
Service de Gynécologie Obstétrique 1 - CHU Hassan 2-Fès. Maroc

DOI:


Article DOI: 10.21474/IJAR01/10574      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10574