REVIEW: THE STUDY OF EFFECTOFBOTANICALS AND NUTRACEUTICALS IN FEMALE SEXUAL DYSFUNCTIONAND IN MENOPAUSE
- Vital Neutraceuticals Pvt.Ltd., Mahararshtra, India.
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Substances which are used to treat sexual dysfunction or to improve sexual behaviour and satisfaction in humans and animals are called aphrodisiac. Uses of plant material to treat sexual disorder and in menopausal women is a long back history in the different system of medicine and it was practiced by different type of Vaidyas and traditional healer in almost all the countries in the world, like China, India, Egypt, Rome and Greek. Even though there was an unavailability of the scientific data, these substances have been used as aphrodisiac. During the historic times Soy Isoflavones,Tribulusterrestries, Mucunapruriens, L- Arginine, Grape Seed Extractand other plants have been investigated for its aphrodisiac activity and for its role in menopause by in vivo and in vitro model. Even though the study showed positive response to a particular substance, there is always a need to run the clinical trial before administering the tested drug in human being. The present review article summarizes the plant material which has been tested for its aphrodisiac activity and its effect in menopause in different experimental model (in vitro, in vivo on animal models, or in human clinical trials) and comply its claim in the different system of medicine.
- Leiblum SR, Koochaki PE, Rodenberg CA. (2006). Hypoactive sexual desire disorder in postmenopausal women: US results from the Womens International Study of Health and Sexuality (WISHeS). Menopause;13(1):46?56.
- Laumann EO, Paik A, Rosen R.(1999). Sexual dysfunction in the United States: prevalence and predictors. JAMa;281(6):537?44.
- Lindau ST, Gavrilova N. (2010) Sex, health, and years of sexually active life gained due to good health: evidence from two US population based cross sectional surveys of ageing. BMJ;340:810.
- Cain VS, Johannes CB, Avis NE, et al. (2003). Sexual functioning and practices in a multi-ethnic study of midlife women: baseline results from SWAN. J Sex Res;40(3):266?76.
- Thomas HN, Chang CC, Dillon S, et al. (2014).Sexual activity in midlife women: importance of sex matters. JAMA Intern Med;174(4):631?3.
- Flynn KE, Lin L, Bruner DW, et al. (2016) Sexual satisfaction and the importance of sexual health to quality of life throughout the life course of U.S. adults. J Sex Med;13(11):1642?50.
- Shifren JL, Monz BU, Russo PA. (2008). Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol;112(5):970?8.
- Thomas, H. N., & Neal-perry, G. S. (2018). Female Sexual Function at Midlife and Beyond Sexual function Menopause Perimenopause Sexual dysfunction. 45, 709?722.
- Bell, T. T. (2019). Is Tribulus Terrestris Effective at Increasing Sexual Desire in Adult Women Suffering from Hypoactive Sexual Desire Disorder?1-9
- Portman DJ, Gass ML. (2014). Genitourinary syndrome of menopause: new terminologyfor vulvovaginal atrophy from the International Society for the Study of WomensSexual Health and the North American Menopause Society. J Sex Med;11(12):2865?72.
- Cuerva MJ, Gonzalez D, Canals M. (2018). The sexual health approach in postmenopause:the five-minutes study. Maturitas;108:31?6.
- Kroll R, Archer DF, Lin Y. (2018). A randomized, multicenter, double-blind study toevaluate the safety and efficacy of estradiol vaginal cream 0.003% in postmenopausalwomen with dyspareunia as the most bothersome symptom. Menopause;25(2):133?8.
- Archer DF, Labrie F, Montesino M. (2017). Comparison of intravaginal 6.5mg(0.50%) prasterone, 0.3mg conjugated estrogens and 10mg estradiol onsymptoms of vulvovaginal atrophy. J Steroid Biochem Mol Biol;174:1?8.
- Dennerstein L, Guthrie JR, Hayes RD. (2008). Sexual function, dysfunction, andsexual distress in a prospective, population-based sample of mid-aged, Australian-born women. J Sex Med;5(10):2291?9.
- Avis NE, Brockwell S, Randolph JF Jr. (2009). Longitudinal changes in sexual functioningas women transition through menopause: results from the Study ofWomens Health Across the Nation. Menopause;16(3):442?52.
- Cyranowski JM, Bromberger J, Youk A. (2004). Lifetime depression history andsexual function in women at midlife. Arch Sex Behav;33(6):539?48.
- Thomas HN, Hamm M, Hess R. (2018). Changes in sexual function among midlifewomen: "Im older. and Im wiser". Menopause;25(3):286?92.
- Hamilton LD, Julian AM. (2014). The relationship between daily hassles and sexualfunction in men and women. J Sex Marital Ther;40(5):379?95.
- Sprecher S. (2002). Sexual satisfaction in premarital relationships: associations withsatisfaction, love, commitment, and stability. J Sex Res;39(3):190?6.
- Byers ES. (2005). Relationship satisfaction and sexual satisfaction: a longitudinal studyof individuals in long-term relationships. J Sex Res;42(2):113?8.
- Women, C. (2010). Medicinal Plants as Alternative Treatments for Female Sexual Dysfunction: Utopian Vision or Possible Treatment in. J Sex Med; 7:3695?3714.
- Kelly JP, Kaufman DW, Kelley K, Rosenberg L, Anderson TE, Mitchell AA. (2005). Trends in use of herbal and other natural products. Arch Intern Med; 165:281?6.
- Fukuda S, Watanabe E, Ono N, Tsubouchi M, Shirakawa T.(2006). Use of complementary and alternative medicine and health problems. Nippon KoshuEiseiZasshi; 53:293?300.
- Akhtari, E., Raisi, F., Keshavarz, M., Hosseini, H., Sohrabvand, F., &Bioos, S. (2014). Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo - controlled study Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo - controlled study.DARU Journal of Pharmaceutical Sciences,22(1):1-6.
- Palacios, S., Soler, E., Ram?rez, M., Lilue, M., Khorsandi, D., &Losa, F. (2019). Effect of a multi-ingredient-based food supplement on sexual function in women with low sexual desire. BMC Women's Health,19:1?7.
- Rowland DL, Tai W., Seftel, A. (2004). A Review of Plant-Derived and Herbal Approaches to the Treatment of Sexual Dysfunctions. J Sex Marital Ther. ;29(3):185?205.
- Do J, Choi S, Choi J, Hyun JS. (2013). Effects and mechanism of action of a Tribulus terrestrisextract on penile erection. Korean J Urol.;54(3):183?188.
- Patel DK, Kumar R, Prasad SK, Hemalatha S. (2011). Pharmacologically screened aphrodisiac plant?a review of current scientific literature. Asian Pacific J Trop Biomed.;1(1): S131?S138.
- Gauthaman K, Ganesan AP, Prasad RN. (2003). Sexual effects of puncture vine (Trib?ulus terrestris) extract (protodioscin): an evaluation using a rat model. J Altern Complement Med.;9(2):257?265.
- Adimoelja A. (2000). Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl.;23(S2):82?84.
- Nunes, C. P., Geller, M., Oliveira, L., & Santos, A. (2014). Clinical Assessment of Tribulus terrestrisExtract in the Treatment of Female Sexual Dysfunction. Clinical Medicine Insights: Women s Health.7:45?50.
- Esfandiari, A. (2016). Effect of Tribulus terrestrisExtract on Ovarian Activity in Immature Wistar Rat: A Histological Evaluation. Journal of Animal and Veterinary Advances.10(7):883-886.
- Hassan, M., Moghaddam, G., Khalili, M.(2013). The Effect of Oral Feeding of Tribulus terrestris L. on Sex Hormone and Gonadotropin Levels in Addicted Male Rats.IJFS,7(1):57?62.
- Neychev, V., &Mitev, V. (2015). Pro-sexual and Androgen Enhancing Effects of Tribulus terrestris: Fact or Fiction. Journal of Ethnopharmacology. 15:1-41.
- Divya, B. J., Suman, B., Venkataswamy, M., &Thyagaraju, K. (2017). The Traditional Uses and Pharmacological Activities of Mucuna.Indo American Journal of Pharmaceutical Research.7(1):7516-25.
- Kavitha C and Thangamani C. (2014). Amazing bean Mucunapruriens: A comprehensive review Journal of Medicinal Plants Research; 8(2):138-143.
- State, E. (2019). Effects of Aqueous Leaf Extract of Velvet Bean (MucunaPruriens) on Reproductive Outcome in Adult Female Wistar Rats. Appl. Sci. Environ. Manage. 23 (5):995-998.
- Suresh, S., Prithiviraj, E., & Prakash, S. (2009). Dose- and time-dependent effects of ethanolic extract of Mucunaprureins Linn. seed on sexual behaviour of normal male rats. Dose- and time-dependent effects of ethanolic extract of Mucunapruriens Linn. seed on sexual behaviour of normal male rats. Journal of Ethnopharmacology,122:497?501.
- Shahaji, P. S., &Parnu, S. A. (2011). Estrogenic activity of Mucunapruriens in Swiss albino mice. International Research Journal of Pharmacy, 2(4):191?193.
- https://courses.lumenlearning.com/wm-biology2/chapter/hormonal-regulation-of-the reproductive-system/(Accessed: 9 December 2019)
- https://embryology.med.unsw.edu.au/embryology/index.php?title=File:HPG_female_axis.jpg(Accessed:9 December 2019)
- Liu, X., Lin, X., Mi, Y., Li, J., & Zhang, C. (2018). Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens. Hindawi,1-16.
- Lee, D., & Kim, J. (2019). Effects of Grape Seed Extract Supplementation on Hemodynamic Response and Vascular Endothelial Function in Postmenopausal Women. Iran J Public Health,48(9): 1735?1737.
- Peng, N., Clark, J. T., Prasain, J., Kim, H., White, C. R., Wyss, J. M. (2005). Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J PhysiolRegulIntegr Comp Physiol., 289: 771?775.
- Salmabadi, Z., Sc, M., Kouchesfahani, H. M., Parivar, K. (2017). Effect of Grape Seed Extract on Lipid Profile and Expression of Interleukin-6 in Polycystic Ovarian Syndrome Wistar Rat Model.International Journal of Fertility and Sterility.11(3): 176?183.
- Ingle JN, Buzdar AU, Schaid DJ, Goetz MP, Batzler A, Robson ME, Northfelt DW, Olson JE, Perez EA, Desta Z, Weintraub RA, Williard CV, Flockhart DA, Weinshilboum RM. (2010). Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer. Cancer Res.; 70(8):3278?86.
- Ito, T. Y., Trant, A. S., & Lake, M. (2011). Journal of Sex & Marital A Double-Blind Placebo- Controlled Study of ArginMax , a Nutritional Supplement for Enhancement of Female Sexual Function.Journal of Sex & Marital Therapy, 27: 541?549.
- Giuliano, F., Rampin, O., & Allard, J. (2011). Neurophysiology and Pharmacology of Female Genital Sexual Response Neurophysiology and Pharmacology. Journal of Sex & Marital Therapy, 28(s):101?121.
- Ito, T. Y., Polan, M. L., & Whipple, B. (2006). The Enhancement of Female Sexual Function with ArginMax , a Nutritional Supplement , Among Women Differing in Menopausal Status. Journal of Sex & Marital Therapy, 32:37?41.
- Hoyle, C. H. V, Robson, T., & Whitley, K. (1996). Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves. Anat.,188:633?644.
- Kim, N. N., Christianson, D. W., &Traish, A. M. (2004).Role of Arginase in the Male and Female Sexual Arousal Response. Nutr.134:2873?2879.
- Atmaca, A., Kleerekoper, M., Bayraktar, M., &Kucuk, O. (2008). Soy isoflavones in the management of postmenopausal osteoporosis. Menopause: The Journal of The North American Menopause Society. 15(4): 748?757.
- Alexandersen P, Toussaint A, Christiansen C. (2001).IpriflavoneMulticenter European Fracture Study. Ipriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial. JAMA,285:1482-1488.
- Fanti P, Monier-Faugere MC, Geng Z. (1998). The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos Int.;8: 274-281.
- J. Heindel, F.S. vom Saal. (2008). Meeting report: batch-to-batch variability in estrogenic activity in commercial animal diets?importanceand approaches for laboratory animal research, Environmental Health Perspectives. 116 (3):389?393.
- Abadjieva D, Kistanova E. (2016). Tribulus terrestris alters the expression of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in rabbit ovaries of mothers and F1 female offspring. PLoS One, 11(2):1-17.
- Sirotkin, A. V, Alexa, R., & Halim, A. (2019). Puncturevine (Tribulus terrestris L.) affects the proliferation, apoptosis, and ghrelin response of ovarian cells. Reproductive Biology, 0?1.
- Postigo, S., Maria, S., Rosa, R., Silvia, L., Yamada, S., Maximiliano, G., & Tsutomu, S. (2016). Assessment of the Effects of Tribulus Terrestris on Sexual Function of Menopausal Women Avalia??o dos efeitos do Tribulus Terrestrisnasexualidade de mulheres no climat?rio. Menopause Review/PrzeglądMenopauzalny,16(1):140?146.
- Freeman, M. and Motsei, M. (1992). Planning Health Care in South Africa - Is There a Role for Traditional Healers? Soc Sci Med., 34 (11):1183-1190.
- Javed, I., Rahman, Z.U., Khan, M.Z., Muhammad, F., Aslam, B., Iqbal, Z., Sultan, J.I. and Ahmad, I. (2009). Antihyperlipidaemic Efficacy of Trachyspermum Ammi in Albino Rabbits. Vet. Brno, 78:229?236.
- Anderson, J.J. and Garner, S.C. (1997). Phytoestrogens and Human Function. Nutr Today, 32 (6):232- 239.
- Joseph, L.M. (1998). Black Cohosh and Chasteberry: Herbs Valued by Women for Centuries. Clinical Nutritional Insights. Advanced Nutrition Publications, Inc. 6 (15): 1-4.
- Erowid (2002). MucunaPruriens. Created 2002-APR- 22. International Legume database and Information Service. Genus Mucuna. Version 10.01.
- Katzenschlager, R; Evans, A; Manson, A (2004). Mucunapruriensin Parkinson disease; a Double Blind Clinical and Pharmacological Study. Neurol. Neurosurg. Psychiatry 75:1672-1677.
- Lednicer D,? ? The physiology of? uterus? and? mammary glands,? in? contraception,? chemical? of? fertility.? The? Blackston Division of McGraw Hill Book Company, New York. 1966.
- Singh, S., Gupta, P. S., & Gupta, R. (2019). Evaluation of anti-anxiety activity of Journal of Drug Delivery and Therapeutics. 9, 104?107.
- Kim, S. W., Jeong, S., Munarriz, R., Kim, N. N., Goldstein, I., &Traish, A. M. (2003). Role of the nitric oxide-cyclic GMP pathway in regulation of vaginal blood flow. 355?361.
- Celermajer DS, Sorensen KE, Gooch VM. (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet; 340: 1111?15.
- Reddy KG, Nair RN, Sheehan HM, Hodgson JM.(1994) Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol; 23: 833?43.
- Celermajer DS, Sorensen KE, Bull C, Robinson J, Dean. eld JE.(1994) Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol; 24: 1468?74.
- Quyyumi AA, Darlak N, Andrews NP.(1995). Nitric oxide activity in the human coronary circulation: impact of risk factors for coronary artherosclerosis. J Clin Invest; 95: 1747?55.
- AI Suwaidi J, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A.(2000) Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation; 101: 948?54.
- Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P. (1995). The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med; 332: 488?93.
- Egashira K, Inou T, Hirooka Y et al.(1993) Effects of age on endotheliumdependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation; 88: 77?81.
- Taddei S, Virdis A, Mattei P et al. (1995). Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation; 91: 1981?87.
- Taddei S, Galetta F, VirdisA .(2000) Physical activity prevents agerelatedimpairment in nitric oxide availability in elderly athletes. Circulation; 101: 2896?901.
- Lyons D, Roy S, Patel M, Benjamin N, Swift CG. (1997). Impaired nitricoxide-mediated vasodilatation and total body nitric oxide productionin healthy old age. Clin Sci; 93: 519?25.
- Celermajer Ds, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D,Robinson J, Dean. eld JE. (1994). Aging is associated with endothelial dysfunctionin healthy men years before the age-related decline in women.J Am Coll Cardiol; 24: 471?76.
- Chauhan A, More RS, Mullins PA, Taylor G, Petch C, Scho. eld PM. (1996)Aging-associated endothelial dysfunction in humans is reversed by Larginine.J AM Coll Cardiol; 28: 1796?804.
- Verma S, Buchanan MR, Anderson TJ.(2003) Endothelial function testing as a biomarker of vascular disease. Circulation 108: 2054?2059.
- Terauchi M, Horiguchi N, Kajiyama A, Akiyoshi M, Owa Y, Kato K, Kubota T. (2014). Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause;21(9):990-6.
- Jin, G., Asou, Y., Ishiyama, K., Okawa, A., Kanno, T., &Niwano, Y. (2018). Proanthocyanidin-Rich Grape Seed Extract Modulates Intestinal Microbiota in Ovariectomized Mice.Journal of Food Science. 4?7.
- Wahner-roedler, D. L., Bauer, B. A., Loehrer, L. L., Cha, S. S., Hoskin, T. L., & Olson, J. E. (2014). The Effect of Grape Seed Extract on Estrogen Levels of Postmenopausal Women: A Pilot Study. Journal of Dietary Supplements, 11(2), 184?197.
[Ganesh Kamath, Supriya Yadav, Bharat Acharaya and Rashmi Mungekar (2020); REVIEW: THE STUDY OF EFFECTOFBOTANICALS AND NUTRACEUTICALS IN FEMALE SEXUAL DYSFUNCTIONAND IN MENOPAUSE Int. J. of Adv. Res. 8 (Mar). 803-816] (ISSN 2320-5407). www.journalijar.com
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