17Mar 2020

STROMAL CD 10 EXPRESSION IN INVASIVE CARCINOMA BREAST AND ITS CORRELATION WITH CLINICOPATHOLOGICAL FEATURES

  • Associate Professor, Department Of Pathology Government Medical College Thrissur, Kerala.
  • Asisstant Surgeon, Primary Health Centre, Vaniyampara, Thrissur, Kerala.
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Introduction: Tumor stroma plays a key role in modulating tumour invasion and metastasis in carcinoma breast. Matrix metalloproteinase CD10 may cause more invasiveness by facilitating matrix degradation and remodelling. Many studies showed higher expression of this marker in higher grade tumours and in tumours with lymph node metastasis. Objectives: a) To study the expression of stromal CD10 in invasive breast carcinomas b)To assess prognostic significance of Stromal CD10 expression and its correlation with clinicopathological features Materials and Method: Stromal expression of CD10 studied in 96 mastectomy specimens andthe association with clinicopathological features evaluated using the chi-square test. P value <0.05 was considered statistically significant. Observations: CD10 scoring was increased in high grade tumours which is statistically significant with(p value 0.017). No significant association could be established statistically for age, menopausal status, tumour size and lymph node status.

  1. Mohammadizah, Majidsalavati, et al. CD10 expression in stromal component of invasive breast carcinoma; A potential prognostic determinant. Journal of research medical sciences, 2012; 2: 194-99.
  2. Iwaya, H. Ogawa, M. Izumi, M. Kuroda, K. Mukai. Stromal expression of CD10 in invasive breast carcinoma: a new predictor of clinical outcome. VirchowsArchiv, 2002; 440(6): 589?593.
  3. B. Huang, X. J. Zhou, J.Y.Chen, et al.CD10-positive stromal cells in gastric carcinoma: correlation with invasion and metastasis. Japanese Journal of Clinical Oncology, 2005; 35(5): 245?250.
  4. A. Makretsov, M. Hayes, B. A. Carter, S. Dabiri, C. B. Gilks, D. G. Huntsman. Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade. Modern Pathology, 2007; 20(1): 84?89.
  5. Tokuhara, M. Adachi, H. Hashida, et al. Neutral endopeptidase/CD10 and aminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer. Japanese Journal of Thoracic and Cardiovascular Surgery, 2001; 49(8): 489?496.
  6. Puri V,Jain M,Thomas S.Stromal Expressioin of CD10 in Invasive Breast Carcinoma and its correlation with ER,PR,HER 2-neu and Ki67.Int J Breast Cancer,2011;20:ID 437957.
  7. Ali Taghizadeh Kermani,Amir Hossein Jafarian,et al.The Stromal overexpression of CD10 in invasive breast cancer and its association with clinicopathological factors.Iranian J of cancer prevention.2014;7(1): 17-21.
  8. V. Anuradha Devi S, Chandra Sekhar C, Saritha S, Sanhya Anil H, Sandhya Rani. A study on stromal CD10 expression in invasive breast carcinoma. IAIM, 2016; 3(6):142-147.
  9. Sayantan H. Jana, Bharti M. Jha, Chandni Patel, Dipan Jana, Anshul Agarwal. CD10- A new prognostic stromal marker in breast carcinoma, its utility, Limitations and role in breast cancer pathogenesis. Indian Journal of Pathology And Microbiology ? 57(4), October-December 2014, DOI: 10.4103/0377-4929.142639.

[Suma M.T and Cheryl Benny K (2020); STROMAL CD 10 EXPRESSION IN INVASIVE CARCINOMA BREAST AND ITS CORRELATION WITH CLINICOPATHOLOGICAL FEATURES Int. J. of Adv. Res. 8 (Mar). 1095-1098] (ISSN 2320-5407). www.journalijar.com

DR SUMA MT
ASSOCIATE PROFESSOR,DEPT OF PATHOLOGY,GOVT MEDICAL COLLEGE THRISSUR

DOI:

Article DOI: 10.21474/IJAR01/10729      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10729

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