24Mar 2020

COMPARATIVE PHARMACOLOGICAL INVESTIGATIONS OF N-HEXANE FRACTIONS OF BAUHINIA SCANDENS LINN.STEMS AND SENNA SOPHERA L. STEMS

  • Department of Pharmacy, International Islamic University Chittagong, Chittagong - 4318, Bangladesh.
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
  • Department of Pharmacy, Stamford University Bangladesh, Dhaka - 1217, Bangladesh.
  • Department of Botany, University of Chittagong, Chittagong - 4331, Bangladesh.
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Objectives:Bauhinia scandens Linn,and Senna sopherahas been locally known as monkey ladders and Kalkasunda in Bangladesh.They have several significant traditional uses as a source of the medicinal agent. This study is to implement the thrombolytic and cytotoxic activity of n-Hexane fraction of Bauhinia scandensstems and Senna sopherastems (NHBS, and NHSS). Methods: In this study, in vitro clot lysis method and brine shrimp lethality method were implemented to check the thrombolytic and cytotoxic potentiality of NHBS and NHSS. Results: In the thrombolytic test, NHBS (24.52 ? 2.86%; P< 0.001) attained a significant percentage of clot lysis but NHSS (16.59 ? 4.07%; P< 0.001) showed moderate clot lysis potentiality in human blood. Again, the LD50 value of NHBS and NHSS was seen at 92.55 ?g/mL and 338.54 ?g/mL of doses respectively in brine shrimp lethality bioassay. Conclusion: Present results suggested, NHBS showed comparatively potent thrombolytic activity than NHSS, besides, a comparative study ofthe LD50 value of NHBS and NHSS suggested that the NHBS has strong anti-tumor potentiality other than NHSS.

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[Nazim Uddin Emon, Israt Jahan, Safaet Alam, Md. Mohotasin Hossain, Sheikh Md. Kamrul Hasan, Md. Munsur Alam, Md. Solaman Uddin Sawon, Sajib Rudra, Mohammad Nazmul Islam and Mohammed Aktar Sayeed (2020); COMPARATIVE PHARMACOLOGICAL INVESTIGATIONS OF N-HEXANE FRACTIONS OF BAUHINIA SCANDENS LINN.STEMS AND SENNA SOPHERA L. STEMS Int. J. of Adv. Res. 8 (Mar). 1108-1113] (ISSN 2320-5407). www.journalijar.com

Nazim Uddin Emon
Department of Pharmacy, International Islamic University Chittagong, Chittagong - 4318, Bangladesh.

DOI:

Article DOI: 10.21474/IJAR01/10731      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10731

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