02Mar 2020

CLINICOPATHOLOGICAL CORRELATION OF UPPER GASTROINTESTINAL TRACT ENDOSCOPIC BIOPSIES IN A TERTIARY CARE HOSPITAL IN RURAL AREA OF NORTH INDIA

  • Lecturer, Department of Pathology, Government Medical College, Jammu, Jammu and Kashmir, India.
  • Registrar, Department of Medicine, Government Medical College, Jammu, Jammu and Kashmir, India.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Upper GI endoscopy is a widely used investigation for a variety of upper GI symptoms like dysphagia, dyspepsia, abdominal pain, etc. and when combined with biopsy, its diagnostic accuracy get increased manifold. So the objective of the present study is to diagnose the lesions of upper GIT by studying endoscopic biopsies in relation to age and sex distribution, correlating them with endoscopic diagnoses. Method: The study included 200 endoscopic biopsies of upper gastrointestinal tract of patients. Result: There were 26 esophageal, 130 gastric, 44 duodenal biopsies. Non-neoplastic lesions were found to be common (83.0%) out of which gastritis was the most common lesion. Most patients presented in the age group of 31-40 years. Majority of the lesions of upper GIT were non-neoplastic. Percentage of concordance between endoscopic & histologic diagnoses was calculated. In esophageal biopsies, non-neoplastic lesions showed 83.3% while neoplastic lesions showed 95.0% concordance. In gastric biopsies, cases of gastritis, ulcer, polyps and carcinoma showed 100%, 96.3%, 71.4% and 100% concordance respectively. In duodenal biopsies, duodenitis, scalloping, polypoidal and carcinomatous lesions showed 100%, 60.7%, 0% and 100% concordance between the two diagnostic modalities respectively. Conclusion: The conclusion of the study was that endoscopic examination alone might miss out in diagnosing majority of the lesions. So, histological examination in adjunct with endoscopy should be considered as much more valuable diagnostic tool rather than endoscopy alone.

  1. Vidyavathi K, Harendrakumar ML, Lakshmana Kumar YC. Correlation of endoscopic brush cytology with biopsy in diagnosis of upper gastrointestinal neoplasms. Indian J Pathol Microbiol. 2008;51(4):489?92.
  2. Cheong YM, Ng YP, Ong SC, Chang PT, Pillai SS. Detection of Helicobacter pylori from endoscopic biopsies and the biochemical characteristics of these isolates. Malays J Pathol. 1990;12(2):97?100.
  3. Ahluwalia C, Jain M, Mehta G, Kumar N. Comparison of endoscopic brush cytology with biopsy for detection of Helicobacter pylori in patients with gastroduodenal diseases. Indian J Pathol Microbiol. 2001;44(3):283?88.
  4. Aaltonen LA, Hamilton SR, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon: IARC Press; 2000.pp.314.
  5. Shariff S. Gastrointestinal System. In: Fundamentals of Surgical Pathology. New Delhi: Jaypee Brothers Publishers; 2010. pp.135?88.
  6. Froehlich F, Pache I, Burnand B, Vader J, Fried M, Kosecoff J, et al. Underutilization of upper gastrointestinal endoscopy. Gastroenterology. 1997;112(3):690?97.
  7. Wei W-Q, Abnet CC, Lu N, Roth MJ, Wang G-Q, Dye BA, et al. Risk factors for oesophageal squamous dysplasia in adult inhabitants of a high risk region of China. Gut. 2005;54(6):759?63.
  8. Al-Ammar NS, Hammadi SS, Al-Saimary I. Demographical study of H. pylori associated gastritis. Adv Bioresearch. 2011;2(1):47?61.
  9. Muszyński J, Biernacka D, Siemińska J, G?rnicka B, Bogdańska M. [Effect of age and sex on the occurrence of gastritis changes in gastric mucosa]. Pol Arch Med Wewnętrznej. 1996;95(6):542?48.
  10. Ljubicić N, Kujundzić M, Roić G, Banić M, Cupić H, Doko M, et al. Benign epithelial gastric polyps--frequency, location, and age and sex distribution. Coll Antropol. 2002;26(1):55?60.
  11. Cao H, Wang B, Zhang Z, Zhang H, Qu R. Distribution trends of gastric polyps: an endoscopy database analysis of 24121 northern Chinese patients. J Gastroenterol Hepatol. 2012;27(7):1175?80.
  12. Bazaz-Malik G, Lal N. Malignant tumours of the digestive tract. A twenty five year study. Indian J Pathol Microbiol. 1989;32(3):179?85.
  13. Hammadi SS, Jasim AH. Endoscopic biopsy and brushing cytology compared to open tissue biopsy: A study of 50 patients with upper gastrointestinal tract malignancies. Med J Basrah Univ. 2009;27(2):80?3.
  14. Pedram A, Mahmodlou R, Enshayi A, Sepehrvand N. Esophageal cancer in northwestern Iran. Indian J Cancer. 2011;48(2):165?69.
  15. ?zoran Y, Albayrak L, Turgutalp H, Bakir T. Atrophic gastritis, intestinal metaplasia, Gastric carcinoma and its variants in dyspeptic cases of eastern Black Sea region. J Islam Acad Sci. 1992;5(2):118?22.
  16. Ryder NM, Ko CY, Hines OJ, Gloor B, Reber HA. Primary duodenal adenocarcinoma: a 40-year experience. Arch Surg. 2000;135(9):1070?75.
  17. Lieberman DA, De Garmo PL, Fleischer DE, Eisen GM, Helfand M. Patterns of endoscopy use in the United States. Gastroenterology. 2000;118(3):619?24.
  18. Shennak MM, Tarawneh MS, Al-Sheikh TM. Upper gastrointestinal diseases in symptomatic Jordanians: A prospective endoscopic study. Ann Saudi Med. 1997;17(4):471?74.
  19. Lee SB, Kang HY, Kim KI, Ahn DH. The Diagnostic Accuracy of Endoscopic Biopsy for Gastric Dysplasia. J Gastric Cancer. 2010;10(4):175?81.
  20. Adisa JO, Musa AB, Yima UI, Egbujo EC. Helicobacter Pylori Associated Gastritis in North-Eastern Nigeria: A Histopathologic Study. E-Int Sci Res J. 2011;3(1):1?4.
  21. Pope CE. Gastroesophageal reflux disease (reflux esophagitis). In: Sleisenger MH, Fordtran JS, editors. Gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: Saunders; 1983. pp.449.
  22. Morson BC, Dawson IMP. Gastrointestinal Pathology. 2nd ed. Oxford: Blackwell Scientific; 1979. pp.610.
  23. Paoluzi P, Pallone F, Palazzesi P, Marcheggiano A, Iannoni C. Frequency and extent of bulbar duodenitis in duodenal ulcer, endoscopic and histological study. Endoscopy. 1982;14(6):193?95.

[Abhimanyu Sharma and Kapil Gupta (2020); CLINICOPATHOLOGICAL CORRELATION OF UPPER GASTROINTESTINAL TRACT ENDOSCOPIC BIOPSIES IN A TERTIARY CARE HOSPITAL IN RURAL AREA OF NORTH INDIA Int. J. of Adv. Res. 8 (Mar). 1155-1160] (ISSN 2320-5407). www.journalijar.com

kapil gupta

DOI:

Article DOI: 10.21474/IJAR01/10736      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10736

Download Full Paper

Download PDF No. of Downloads: 65 | No. of Views: 224