14Apr 2020

AMELIORATIVE ACTIVITY OF ASCORBIC ACID (AA) ON PARAQUAT (PQ) INDUCED SERUM BIOCHEMICAL ALTERATIONS IN EXPERIMENTAL RATS

  • Post-graduate, Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad-500030, India.
  • Assistant Professor and Head, Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Mamnoor, Warangal-506166, India.
  • Professor and Head, Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad-500030, India.
  • Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad-500030, India.
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The present study aimed to investigate the protective effect of ascorbic acid on paraquat induced serum biochemical alterations in experimental rats. Forty-eight (48) male albino Wistarrats were randomized into four (4) groups consisting of twelve (12) in each. Group 1- Control. Group 2 ? Paraquat at the rate of 40 mg/kg b.wt. Group 3 ? Ascorbic acid at the rate of 250 mg/kg b.wt. Group 4 ? Paraquat at the rate of 40 mg/kg b.wt + Ascorbic acid at the rate of 250 mg/kg b.wt. The treatment regimens were administered by oral gavage once daily for twenty-one (21) days. Significantly (P<0.05) increased activity of aspartate transaminase, alanine transaminase, alkaline phosphatase, blood urea nitrogen and serum creatinine and significantly (P<0.05) decreased activity of total protein was observed in group 2 on 7th and 21st day of experiment. Co-treatment with ascorbic acid showed a remarkable protection against the parameters investigated possibly via antioxidant defence mechanism.

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[Kothinti Busa Ashok Kumar Reddy, Mylaram Jeevanalatha, Mekala Lakshman and Matukumalli Usha Rani (2020); AMELIORATIVE ACTIVITY OF ASCORBIC ACID (AA) ON PARAQUAT (PQ) INDUCED SERUM BIOCHEMICAL ALTERATIONS IN EXPERIMENTAL RATS Int. J. of Adv. Res. 8 (Apr). 107-112] (ISSN 2320-5407). www.journalijar.com

Kothinti Busa Ashok Kumar Reddy
Post graduate, Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad-500030, India.

DOI:

Article DOI: 10.21474/IJAR01/10752      
DOI URL: http://dx.doi.org/10.21474/IJAR01/10752

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