STUDY THE RELATION BETWEEN THYROID FUNCTION AND RENAL FUNCTION IN CHRONIC KIDNEY DISEASE AND THE EFFECT OF DIALYSIS IN THESE PATIENTS

The aim of this work: Is to study the relation between thyroid function and renal function in chronic kidney disease and the effect of dialysis in these patients.

Materials and method: 60participants of both sexes, were categorized into three groups, group Ihealthy control participants, group II Chronic kidneydisease non dialysis patient and group III Chronic kidney disease(CKD) with dialysis. Last twogroups arefurther subdivided into three subgroups: a) euothyroid, b) hypothyroid and c) hyperthyroid. Urine was collected for 24 hours and blood samples were analyzed for serum creatinine, serum urea, serum Total Tri-iodithyronine (T3), Thyroxin (T4), serum Thyroid Stimulating Hormone (TSH) and urine albumin. Glomerular filtration rate (GFR) will be measured as creatinine clearance

Results: GFR is significantly reduced in all group studied inCKDpatientswith and without dialysis compared to control. In hyperthyroid patients it is significantly increased compared to other groups without dialysis and also compared to hypothyroid patients with dialysis. Urea, creatinine and urinary albumin are significantly increase in all groups compared to control. TSH is significantly increased in hypothyroid and significantly reduced in hyperthyroidism and unchanged in euothyroid patients as compared to control. The opposite will be observe for T3 and T4 with exception of increase T4 in hypothyroid patients without dialysis

Conclusion: There are many remaining information with regards to the interaction between kidney disease and thyroid dysfunction. Thyroid function should be carefully monitored in persons with poor renal function. Further mechanistic studies are consider to understand the pathogenesis of thyroid functional disorders in kidney disease, and how CKD may affect thyroid dysfunction.