CHANGES IN THE EXPRESSION OF NOTCH AND HIF-1Α SIGNALING MOLECULES IN PROSTATE CANCER PROGRESSION
Wei Chen
, Li-Na He
, Cheng-Wu He
, Xiang Zeng
, Guang-Qing Fu
, Ming-Qiang Su
, Xin-Yang Fu
, Jian-Hui Liu
and Yong Liang
- Department of Urology, Zigong Fourth Peoples Hospital, Sichuan, China.
- Department of Reproductive Medicine, Zigong Maternity and Child Healthcare Hospital, Sichuan, China.
- Department of Science and Education, Zigong Fourth Peoples Hospital, Sichuan, China.
- Department of Urology, The Eighth Affiliated Hospital of Sun Yet-Sen University, Guangdong, China.
- Department of Urology, Kaiping Central Hospital, Guangdong, China.
- Abstract
- Keywords
- How to Cite This Article
- Corresponding Author
Objective: To explore the expression and clinical significance of Notch and HIF-1α signaling molecules in the progression of prostate cancer.
Method: A total of 68 cases with prostate cancer were enrolled to detecting the expression level of Notch1, HIF-1α and Hes1 mRNA by qRT-PCR, in which the protein expression was measured by western blotting and immunohistochemistry staining, respectively. Correlation between molecules above and clinical pathological parameters were further analyzed.
Results: Both Notch signaling and HIF-1α signaling molecules were overexpressed in prostate cancer on the protein level as well as mRNA level when compared to the para-caner tissues (P<0.05). The expression of these molecules were positive related to local lymphatic metastasis (P<0.05). However, this difference was not significant both in tumor volume and patient’s age.
Conclusion: Both Notch signaling and HIF-1α signaling pathway related molecules were overexpressed in prostate cancer, which might play an important role in the progression of prostate cancer.
Wei Chen, Li-Na He, Cheng-Wu He, Xiang Zeng, Guang-Qing Fu, Ming-Qiang Su, Xin-Yang Fu, Jian-Hui Liu and Yong Liang (2020); CHANGES IN THE EXPRESSION OF NOTCH AND HIF-1Α SIGNALING MOLECULES IN PROSTATE CANCER PROGRESSION, Int. J. of Adv. Res., 8 (07), 1636-1641, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/11433
Zigong Fourth Peopleâs Hospital
China
