THE SIGNIFICANCE OF CEA AND CA15-3 IN EARLY BREAST CANCER ITS ASSOCIATION WITH CLINICO PATHOLOGICAL CHARACTERISTICS A SINGLE-CENTER STUDY IN MADINAH, SAUDI ARABIA
- Medical Oncology Consultant, Assistant Professor, College Of Medicine, Taibah University.
- Internal Medicine Residents, King Fahad Hospital, Ministry of Health, Madinah, Saudi Arabia.
Abstract
Background and Aims: The utility of measuring carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) levels in patients with breast cancer remains controversial. The present study aims to investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological characteristics.
Methods: Serum preoperative CEA and CA 15-3 concentration levels were measured in a total of 135 breast cancer patients.The association of tumor markers levels with clinicopathological characteristics were analyzed.
Results: Elevated serum levels of CEA and CA15-3 were identified in 26 (19.26%) and 20 (14.8%) patients, respectively. Increased CEA levels were not associated with age, histological type, tumor size, tumor grade, breast cancer stages, or breast cancer types. CA15-3 levels were positively correlated with the size of the primary tumor (P<0.026) but had no significant correlation with the other factors.
Conclusions: The elevation of CA 15-3 was positively correlated with the size of the primary tumor.
Keywords
Article Analytics
How to Cite This Article
Nasser Mulla, Yara Bin Saad, Jamlaa Alharbi and Salwa Alalwi (2020); THE SIGNIFICANCE OF CEA AND CA15-3 IN EARLY BREAST CANCER ITS ASSOCIATION WITH CLINICO PATHOLOGICAL CHARACTERISTICS A SINGLE-CENTER STUDY IN MADINAH, SAUDI ARABIA, Int. J. of Adv. Res., 8 (11), 1082-1087, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/12103
Corresponding Author
This work is licensed under a Creative Commons Attribution 4.0 International License.