ANTIMULLERIANHORMONE: CORRELATION WITH FIRST TRIMESTER MISCARRIAGE

Objective: The present study assessed antiMullerian hormone (AMH) levels as a useful markerand a predictor of abortion in the first trimester among women younger than 35 years.

Methods: Prospective study of women aged 18–34 years with a spontaneous pregnancy at less than 12 gestational weeks in Benha , Egypt, between January 2019 and November 2020 samples of blood taken at the beginning of pregnancy on booking and again at 6 weeks. Cases of anembryonic abortion and assisted conception were excluded.  Blood samples were collected and assayed for serum AMH levels (on booking and at 6 weeks gestation. Data were compared between women with an embryo with no cardiac activity by ultrasound (n=50) and those with a normalpulsating embryo (n=50) by using smith statistical software.

Results: Risk of pregnancy loss in the first trimester was found to be higher for low AMH (<1 ng/mL relative risk [RR], 3.66 95% confidence interval.

Conclusions: LowAMH concentrations found to significantly increase the risk of abortion in the first trimester of pregnancy. Serum AMH might be a valuable marker to predict the risk of early abortion when it is below 1ng/ml.