CORRELATION BETWEEN CEREBRAL VENOUS SINUS THROMBOSIS AND SERUM HOMOCYSTEINE LEVELS IN A TERTIARY CARE HOSPITAL, INDIA A PROSPECTIVE OBSERVATIONAL STUDY

Objective: To study correlation between Cerebral Venous Sinus Thrombosis and Serum Homocysteine levels.

Patients and Methods: 76 patients having Cerebral Venous Thrombosis were admitted to our hospital from September 2017 to September 2019. In each patient fasting serum homocysteine levels and serum B12 levels were taken and analyzed. Every patient was subjected to a detailed clinical history and neurological examination. In each patient fasting serum homocysteine levels and serum B12 levels were done. The serum homocysteine levels were done by kinetic biochemistry using R1 and R 2 reagents. The serum B12 levels were done by using ELISA Technique. On the basis of serum homocysteine levels, the patients were divided into 4 categories: Normal Level, Mild Hyperhomocysteinrmia, Moderate Hyperhomocysteinemia and Severe Hyperhomocysteinemia. On the basis of serum B12 levels, the patients were again divided into 4 categories: Severe Deficiency, Mild Deficiency, Normal range and High levels.

Conclusion: Hyperhomocysteinemia could be a risk factor accounting forCerebral Venous Sinus Thrombosis. The results of this study have shown that homocysteine levels were significantly higher in CVST patients and serum hyperhomocysteinemia is one of the risk factor in the etiology of Cerebral Venous Sinus Thrombosis patients. Though, Serum B12 levels showed no correlation in patients of CVST. Thus, Serum homocysteine estimation needs to be sent from emergency department of all patients with diagnosis of Cerebral Venous Sinus Thrombosis.