IMPLICATIONS AND POTENTIAL ROLE OF HUMAN TELOMERASE REVERSE TRANSCRIPTASE (hTERT) IN BLADDER CARCINOGENESIS
- Advanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, J & K, India.
- School of Life Sciences, Jaipur National University, Jaipur Rajasthan, India.
- Department of Urology and kidney transplant, SKIMS, Srinagar, J & K, India.
- Department of Immunology and Molecular Medicine, SKIMS, Srinagar, J & K, India.
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Bladder cancer is a heterogeneous disease and ranks as 10th most common cancer worldwide. Urothelial carcinoma (UC) is the most common histologic type of BC and majority constitute of papillary tumors that are well-differentiated (low-grade). Several genetic changes may occur in bladder cancer, but hTERT promoter mutations and its expression has been detected in most cases of transitional cell carcinoma. Numerous researches have led to the findings which suggest that the hTERT promoter mutations in conjunction with the common polymorphism and hTERT expression have potential of being used as clinical biomarkers in bladder cancer. Further studies need to explore the potential use of hTERT gene in bladder cancer detection, diagnosis and prognosis. This review focuses on the role of hTERT in bladder tumors in the backdrop of various studies published.
[Iqra Anwar, Usma Manzoor, Arshad A. Pandith, Mohammad S. Wani, Meena Godha and Zafar A. Shah (2021); IMPLICATIONS AND POTENTIAL ROLE OF HUMAN TELOMERASE REVERSE TRANSCRIPTASE (hTERT) IN BLADDER CARCINOGENESIS Int. J. of Adv. Res. 9 (Jun). 428-434] (ISSN 2320-5407). www.journalijar.com
Advanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences, Srinagar 190011, Kashmir, India
