12Oct 2021
A SIMPLE ONE-POT SYNTHESIS OF PYRIMIDO[4,5-C]PYRIDAZINES AND IN SILICO STUDIES OF HUMAN AKT1 INHIBITORS
- Department of Chemistry, Govt. Serchhip College, Serchhip-796181, Mizoram, India.
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A simple one-pot and efficient synthetic method for the synthesis of pyrimido[4,5-c]pyridazine by a multicomponent reaction. The synthesis compounds are study for their inhibitory activities towards AKT1 pathways by using in silico method. It was found that all compounds have binding energy lower than -7.9 kcal/mol and compound 3a is the most active with binding energy -9.65 kcal/mol, which have been performed using autodock vina.
[Laldingluaia Khiangte (2021); A SIMPLE ONE-POT SYNTHESIS OF PYRIMIDO[4,5-C]PYRIDAZINES AND IN SILICO STUDIES OF HUMAN AKT1 INHIBITORS Int. J. of Adv. Res. 9 (Oct). 136-142] (ISSN 2320-5407). www.journalijar.com
Laldingluaia Khiangte
Department of Chemistry, Govt. Serchhip College, Serchhip-796181, Mizoram, India
Department of Chemistry, Govt. Serchhip College, Serchhip-796181, Mizoram, India
