Fast and Cost Effective Electrochemical method for Ascorbic Acid in Pharmaceutical labs

A fast and inexpensive analysis is a prime requirement of all laboratories. This study establishes voltammetric method for quantitative analysis of vitamin-C (Ascorbic Acid) in different pharmaceutical products. Oral tablets, drops, syrups and capsule are analyzed for vitamin-C assay in drugs. Potassium chloride of 0.3M is chosen, as supporting electrolytes. Optimum scan rate is found 100mVs-1. Glassy carbon electrode is chosen as indicator electrode. Half wave potential is 350mV as average. Average peak potential is 400mV. A sensitivity of 21.93mA.M-1 is obtained with detection limit of 0.001mM. Expected interference (due to excepients) is examined. Shifting of half wave potential is observed in case of syrup, capsule and core tablet as matrix interference. While no such effect of shifting in case of in injeactables. System is found to be non reversible. Spiking of samples with standards overcome the problem of having shifting of half wave potential.