Evaluation of anticonvulsant activity of hydroalcoholic extract of Aegle marmelos (Linn. Correa, stem bark)

A prehistoric plant, Aegle marmelos commonly known as “Bael” wildly growing across the country and contribute wide range of pharmacological actions which were proven by scientific data published over the past year. Bael is well acknowledged with its ethno-medicinal uses and therefore be more magnetism promote to use of. Present study primarily design to assess an anticonvulsant activity in vivo followed by Pentylene tetrazole (PTZ), Maximal electroshock (MES) induced convulsion which will initiate seizure with in animal. An assessment of percentage protection against seizure and mortality- a key important evaluation parameter and estimation of ?-aminobutyric acid (GABA) level- inhibitory neurotransmitter belief to provokes seizure in rodent was compare with treatment group of hydro-alcoholic extract (Aegle marmelos, stem bark) at different dose level (200 & 400 mg/kg, i.p.). In rodent higher dose of Aegle marmelos suggests, significant (*p<0.05) reduction in the duration HLTE (hind limb tonic extensor) facilitated by MES model. In addition, markedly decrease in percentage mortality (66.6 %) against PTZ model. There were increases with the GABA level at higher doses as compared to lower dose & normal control treatment group. This would be the next direction for the estimation of GABA level with isolated phytochemical compound.