Vol. 10 (10) pp. 287-296 DOI: 10.21474/IJAR01/15490

POSSIBLE IMMUNE ALTERATION AFTER COCHLEAR IMPLANTATION

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  • Department of Clinical pathology, Hearing and speech institute, Cairo, Egypt.
  • Department of Clinical pathology, National Institute of Urology and Nephrology, Cairo, Egypt.
  • Department of physiology and immunology, Hearing and speech institute, Cairo Egypt.
  • Department of Audio-vestibular medicine, Hearing and speech institute, Cairo, Egypt.
  • Audio-vestibular medicine Unit, Otolaryngology department, Helwan University, Cairo, Egypt.
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Abstract

Aims:Cochlear implant (CI) is a widely accepted device to patients with severe to profound sensorineural hearing loss to replace the normal hearing pathway. Since a portion of the device is implanted under the skin, possible immune alteration may occur. Our aim was to assess the production of some selected pro-inflammatory and anti-inflammatory cytokines in patients with cochlear implants and their impact on hearing outcomes.

Material and Methods: Our study was conducted on 25 cochlear implanted patients who were subjected to IL-1β, IL2, IFN-γ and IL6 laboratory assessment preoperatively, postoperatively, 6 months after CI and 2 years after CI. Simultaneously, impedance and neural response telemetry (NRT) were measured and the data were analyzed statistically in relation to the laboratory findings.

Results:No statistically significant difference was found between the levels of cytokines at different times of assessment except a significant increase of IL-1β at first fitting postoperatively in comparison to preoperative sample. Also, no statistically significant difference was found as regards values of impedance and NRT except a significant decrease of postoperative measures of NRT in comparison to intraoperative measures without any malfunction.

Conclusion:There is a minimal immune alteration immediately after CI without any functional affection which may be attributed to the trauma of the implantation surgery  rather than foreign body immune response.

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How to Cite This Article

Eman S. Abd El-Ghaffar, Azza A.I. Elmenyawi, Hala M. Abd El-Samad, Abir Omara, Eman Ghorab and Heba Ghannoum (2022); POSSIBLE IMMUNE ALTERATION AFTER COCHLEAR IMPLANTATION, Int. J. of Adv. Res., 10 (10), 287-296, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/15490

Corresponding Author

Heba Ghannoum
Audio-vestibular medicine Unit, Otolaryngology department, Helwan University, Cairo, Egypt.
Egypt
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