15Nov 2022

THE BUFFERING CAPACITY OF ERYTHROCYTE MEMBRANE SURROUNDINGS IN RELATION TO FREE PROTONS INSIGHTOF NEW ELUCIDATION OF EIGTH AND NINTH STAGES OF THE MEMBRANE REDOXY POTENTIAL THREE STATE DEPENDENT 9 STEPPED FULL CYCLE OF PROTON CONDUCTANCE IN THE HUMAN BODY

  • New Medicine Medical University, Ulanbator, Mongolia.
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It was became clear that the flow-fate of all many many protons,generated in mitochondria of 50-80 trillion cells (now by us mitochondria flow of protons named as 1-7 stages of proton conductance) have been needed another special structures - another system needs to soak up the extra H+ activity generated as a result of process conducted in the 1-7 stages of proton conductance in order for true buffering to occur, that system consists of intracellular proteins, of which haemoglobin is the key player, concretely speaking,one of these are the erythrocyte membrane surroundings for packaging of protons and alsoHydrochloric acid formationby Gastric parietal cells,also H+/Na antiport in the membrane transports H+ out of cell and Na ion in the level of Peritubular capillary-Interstitial fluid-Tubule epithelial cells-Tubular fluid with accompanying maintaining of serum and cell pH-7,4.By our suggestion, the buffering capacity of erythrocyte membrane surroundings in relation to free protons, formed in the proton conductance have implemented within Ninth stage -located in the Respiratory membrane, Pulmonary circuit, where occurred oxygen uptake from alveolar air under effect of increased bicarbonate entry by bicarbonate/chloride ion shift mechanism, leading to increase of HbO2 formation, resulting to release of proton,electron from food substrates under the undirect action of oxygen released from membrane surroundings of erythrocyte in the 8-th stage of proton conductance.


[Ambaga M., Tumen-Ulzii A. and Buyantushig T. (2022); THE BUFFERING CAPACITY OF ERYTHROCYTE MEMBRANE SURROUNDINGS IN RELATION TO FREE PROTONS INSIGHTOF NEW ELUCIDATION OF EIGTH AND NINTH STAGES OF THE MEMBRANE REDOXY POTENTIAL THREE STATE DEPENDENT 9 STEPPED FULL CYCLE OF PROTON CONDUCTANCE IN THE HUMAN BODY Int. J. of Adv. Res. 10 (Nov). 29-33] (ISSN 2320-5407). www.journalijar.com


Prof. Ambaga.М