Heterocyclization of barbituric acid: Synthesis of novel condensed pyrimidines
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A series of heterocyclic compounds was synthesized from barbituric acid. Reaction of barbituric acid with dibenzalacetone in acidic and basic medium afforded spiro compounds 3 and 4 and pyridopyrimidine derivatives 5, respectively. While, condensation reaction of barbituric acid with ethyl cyanoacetate and ethyl acetoacetate in presence of AcONH4, gave pyridopyrimidine derivatives 7 and 8, respectively. On the other hand, barbituric acid not condensed with dimedone to give compound 10, but gave 2-aminopyrimidine 9. Reaction of barbituric acid with urea and thiourea in presence of HCl and I2 gave pyrimidopyrimidne and thiazolopyrimidine derivatives 11-13, respectively. The structure of newly synthesized compounds was elucidated using spectral analysis (IR, 1H NMR and 13C NMR) and micro analysis.
Reda A. Haggam, Mohamed G. Assy, Enaiat K. Mohamed, Abdussattar S. Mohamed (2015); Heterocyclization of barbituric acid: Synthesis of novel condensed pyrimidines, Int. J. of Adv. Res., 3 (04), 0, ISSN 2320-5407. DOI URL: https://dx.doi.org/
