THE STUDY OF EPIDEMIOLOGICAL, CLINICAL AND BIOCHEMICAL CHARACTERISTICS OF COVID 19 NON SURVIVORS IN A TERTIARY CARE HOSPITAL OF SOUTHERN INDIA

Background: Severe acute respiratory syndrome coronavirus 2, which causes COVID‑19 pandemic has affected more than 90 million people and more than 1.9 million deaths. Despite extensive study, the prognostic role of various clinical, haematological and biochemical parameters remains unclear.

Objective: To study the epidemiological, clinical and biochemical characteristicsof covid 19 non survivors and to study the variations in vital parameters, hematological and biochemical parameters at the time of admission and before death.

Materials and Methods: Retrospective study, data was collected, from files of 100 COVID 19 nonsurvivors admitted in second peak of COVID in tertiary care hospital, MYSURU.

Results: The mean age was 59.48 and majority in age group of >61years. Sex preponderance was as follows males 66% and females 34%. The major comorbidities in our study subjects was hypertension in 43% and diabetes in 45%. 16% were alcoholics and 20% smokers. 91% patients presented with hypoxemia and 90% of the patients needed non-invasive ventilation by 5^th day. 7 patients needed ICU admission. The maximum number of patients (40) had a hospital stay of 13 hours to 3days. There was significant tachycardia(122/minute), hypotension(90/60mmHg), tachypnoea(34/minute) with desaturation (78%) even with oxygen support in all 100 patients .Most of the patients had worsening trend in the mean values of TLC(10,688cells),NLR(12.5),thrombocytopenia(61,453/mm³),urea(1mg/dl),creatinine(2.35mg/dl),total bilirubin(2.18mg/dl), LDH(940mg/dl), d-dimer(2075ng/dl), ferritin(690mg/dl), and trop-T(49mg/dl).

Conclusion: In our study most of the patients hadrespiratory failure andcytokine mediated damage to other organs renal, hepatic, cardiac and haemorrhagic was also critical and hence should be monitored. The biochemical parameters and vitals at time of admission should be monitored frequently can be used as prognostic, predictive and risk stratifying factors of mortality.