Prevalence Of Hyperuricemia And Relation Of Serum Uric Acid With Diabetic Risk Factors

This study investigated the prevalence and determinants of hyperuricemia in type 2 diabetes mellitus(T2DM) patients with central obesity. A hospital-based cross-sectional study was carried out at Index Medical College, Hospital and Research Centre, Indore. T2DM patients with central obesity who were aged over 20 years, whose serum uric acid levels were measured, were recruited. Hyperuricemia was defined as serum uric acid >0.42 mmol/L in men and >0.36 mmol/L in women. The purpose of the present study was to investigate the prevalence of hyperuricemia and the association between uric acid levels and the various diabetic risk factors. This study included 100 diabetic subjects aged 25 to 80 years. The body mass index (BMI), waist circumference, total and HDL cholesterol, serum triglycerides and serum uric acid were measured. Data were analyzed using student t-test, pearson’s coefficient and linear regression model. The prevalence of a serum uric acid level >0.42 mmol/L in men was 18.32% and the prevalence of a serum uric acid level >0.36 mmol/L was 15.9% in women. Serum uric acid was strongly related to serum triglycerides in men as well as in women (r = 0.255 in men and r = 0.254 in women, p < 0.001). Uric acid levels were also significantly associated but to a lesser degree with age, BMI and waist circumference. This study shows that serum uric acid is markedly associated with diabetic risk factors, in particular serum triglycerides. Hyperuricemia is significantly associated with type II diabetes mellitus and can significantly increase morbidity and mortality from diabetes if not managed in time.