STUDY OF METABOLIC PROFILE OF LEAN AND OBESE SUBJECTS WITH NON ALCOHOLIC FATTY LIVER DISEASE AT A TERTIARY HOSPITAL

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is often understood to be the hepatic expression of metabolic syndrome. In both lean & obese individuals, one common theme of NAFLD metabolism is the prevalence of Insulin Resistance (IR).

Aims & Objectives: To assess & compare the Metabolic profile of obese & lean subjects with NAFLD.

Materials & Methods: Hospital based Prospective study done in 60 Patients selected by random sampling procedure matching the inclusion criteria. A pretested pro forma was used Results: 26.7% in the obese group and 13.3% in the lean Group had Positive Family history of Diabetes and Hypertension. Mean waist circumference in obese group was 91.23 ± 7.84 and in lean group was 88.73 ±9.60. BMI in the obese group was 33.14± 2.10 and in lean group was 22.66 ±3.32. SBP in the obese group it was 132.93 ±15.06 and in lean group was 120.66 ±7.03.Triglyceride levels in the obese group it was 173.76 ±29.97 and in lean group was 147.46 ±36.35.FBS levels in the obese group it was 110.23 ±11.36 and in lean group was 85.43 ± 9.00

Conclusion: The Present Study suggesting obese and lean individuals who had comorbidities , have more metabolic dysregulation than obese and lean individuals without having comorbidities.