CORONARY IN-STENT RESTENOSIS: A LITERATURE REVIEW

Intrastent restenosis is a narrowing of the lumen of a coronary vessel previously treated with angioplasty It is the result of two histopathological processes: vascular remodeling and neointimal hyperplasia due to smooth muscle migration and proliferation, with the latter mechanism predominating. It manifests clinically with symptoms of ischemia and angiographic findings showing at least a 50% reduction in the lumen of a vessel previously treated with balloon angioplasty or a stent. Second generation drug eluting stents or drug eluting balloons are recommended for treatment, depending on the type of restenosis being treated.

We present a review of the literature about of the various aspects of this topic which remains a clinical challenge for interventional cardiologists, starting from its origin its historical background.to various treatment options.