RESTITUTIVE PROPERTIES OF CURCUMA LONGA ON CYPERMETHRIN INDUCED SWISS-ALBINO MICE (MUS MUSCULUS)

The present investigation delves into the reparative efficacy of Curcuma longa extract in mitigating the deleterious effects induced by varying concentrations of cypermethrin in Swiss albino mice (Mus musculus). A significant increase was observed at the highest dose of cypermethrin (200 mg/kg of body weight of Swiss albino mice) in biochemical parameters namely Aspartate Aminotransferase (AST), 49 % Alanine Aminotransferase (ALT), 58 % Blood Urea Nitrogen (BUN), 108 % Creatinine 247 %. The discernible outcome is evidenced by a gradual recovery in the damage inflicted by cypermethrin. Significant changes were observed, including an approximate 16% decrement in AST, 7% reduction in ALT, substantial 45% decline in BUN levels, and a pronounced 76.16% decrease in creatinine levels. Further, haematological indices demonstrate a commendable recovery pattern, with a 10% resurgence in neutrophils, 3% restitution in lymphocytes, 6% recuperation in basophils, 2% restoration in monocytes, and 10% revival in eosinophils. These findings substantiate a promising therapeutic role for C. longa extract within the realm of pharmaceutical industries, signifying its potential utility in countering cypermethrin-induced physiological disbalance.